Title:
単糖のアノマー誘導体
Document Type and Number:
Japanese Patent JP4610197
Kind Code:
B2
Abstract:
This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.
Inventors:
Mutermans Wim
West Michael Leo
Tonle Jean
Adamson George
Shafer curl
Avenante Giovanni
West Michael Leo
Tonle Jean
Adamson George
Shafer curl
Avenante Giovanni
Application Number:
JP2003580313A
Publication Date:
January 12, 2011
Filing Date:
March 28, 2003
Export Citation:
Assignee:
Alchemia Limited
International Classes:
C07D309/14; C07D405/12; C07H9/04; C07F7/18; C07H15/12; C07H15/18; C07H15/20
Domestic Patent References:
| JP2001501174A | ||||
| JP7242684A | ||||
| JP61293991A | ||||
| JP60208992A | ||||
| JP53031664A | ||||
| JP2002502393A |
Foreign References:
| US5491152 | ||||
| WO1991007420A1 | ||||
| US5780607 | ||||
| WO2002008446A1 |
Other References:
GRUNER,S.A. et al,sugar amino acids and carbohydrate scaffolds,Chem Rev,2002年,Vol.102, No.2,p.491-514
Smith M. D.,Synthesis of oligomers of tetrahydrofuran amino acids: frunose carbopeptoids,Chemical communications,1998年,Vol.18,p.2039-2040
Shaban M. A. E-M.,The synthesis of antigenic Glycopeptides, 2-acetamido-N-(β-L-aspartyl)-2-deoxy-4-O-β-(D-galactopyranosyl)-β-D-glucopyranosylamine (N-acetyllactosaminyl-L-asparagine),Bulletin of the Chemical Society of Japan,1981年,Vol.54, No.11,p.3570-3576
Tanaka, K.,Synthesis and evaluation of a bicyclic deoxymannojirimycin derivative as a potential glycosidase inhibitor,Canadian Journal of Chemistry,1998年,Vol.76, No.4,p.431-436
Urban, D.,Stereocontrolled Synthesis of α-C-Galactosamine Derivatives via Chelation-Controlled C-Glycosylation,Journal of Organic Chemistry,1998年,Vol.63, No.8,p.2507-2516
Bamford, Mark J.,Synthesis of 6-, 7- and 8-carbon sugar analogs of potent anti-influenza 2,3-didehydro-2,3-dideoxy-N-acetylneuraminic acid derivatives,Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry,1995年,No.9,p.1181-1187
Sherman, Judith S.,Studies of model compounds for the analysis of ester-containing polysaccharides by the reductive-cleavage method,Carbohydrate Research,1992年,Vol.231,p.221-235
Broxterman, H. J. G.,Synthesis of 2-acetamido-2-deoxy-D-mannose analogs as potential inhibitors of sialic acid biosynthesis,Journal of Carbohydrate Chemistry,1991年,Vol.10, No.2,p.215-237
Wang, Nan,Authentic standards for the reductive-cleavage method. The positional isomers of partially methylated and acetylated or benzoylated1,4-anhydro-D-xylitol,Carbohydrate Research,1995年,Vol.274,p.45-58
Smith M. D.,Synthesis of oligomers of tetrahydrofuran amino acids: frunose carbopeptoids,Chemical communications,1998年,Vol.18,p.2039-2040
Shaban M. A. E-M.,The synthesis of antigenic Glycopeptides, 2-acetamido-N-(β-L-aspartyl)-2-deoxy-4-O-β-(D-galactopyranosyl)-β-D-glucopyranosylamine (N-acetyllactosaminyl-L-asparagine),Bulletin of the Chemical Society of Japan,1981年,Vol.54, No.11,p.3570-3576
Tanaka, K.,Synthesis and evaluation of a bicyclic deoxymannojirimycin derivative as a potential glycosidase inhibitor,Canadian Journal of Chemistry,1998年,Vol.76, No.4,p.431-436
Urban, D.,Stereocontrolled Synthesis of α-C-Galactosamine Derivatives via Chelation-Controlled C-Glycosylation,Journal of Organic Chemistry,1998年,Vol.63, No.8,p.2507-2516
Bamford, Mark J.,Synthesis of 6-, 7- and 8-carbon sugar analogs of potent anti-influenza 2,3-didehydro-2,3-dideoxy-N-acetylneuraminic acid derivatives,Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry,1995年,No.9,p.1181-1187
Sherman, Judith S.,Studies of model compounds for the analysis of ester-containing polysaccharides by the reductive-cleavage method,Carbohydrate Research,1992年,Vol.231,p.221-235
Broxterman, H. J. G.,Synthesis of 2-acetamido-2-deoxy-D-mannose analogs as potential inhibitors of sialic acid biosynthesis,Journal of Carbohydrate Chemistry,1991年,Vol.10, No.2,p.215-237
Wang, Nan,Authentic standards for the reductive-cleavage method. The positional isomers of partially methylated and acetylated or benzoylated1,4-anhydro-D-xylitol,Carbohydrate Research,1995年,Vol.274,p.45-58
Attorney, Agent or Firm:
Eiji Saegusa
Kakehi Yuro
Kenji Saito
Kakehi Yuro
Kenji Saito