Title:
シクロオキシゲナーゼ-2の阻害剤として選択性の優れたビピリジニル誘導体
Document Type and Number:
Japanese Patent JP4060798
Kind Code:
B2
Abstract:
The present invention relates to a novel bipyridinyl derivative having a structure of formula (1) and its pharmaceutically acceptable salts, optical isomer and method for preparing it as a highly selective cyclooxygenase-2 inhibitor, wherein R is defined in this specification.
Inventors:
Cho, Il-Han
Rim, Gee-Woon
No, Ji-Youn
Kim, John-Hoon
Park, Sun-Walk
Ryu, Hyun-Chul
Kim, J-Haku
Kim, John Ho
One, So-Youn
Kim, Dal-Hyun
Rim, Gee-Woon
No, Ji-Youn
Kim, John-Hoon
Park, Sun-Walk
Ryu, Hyun-Chul
Kim, J-Haku
Kim, John Ho
One, So-Youn
Kim, Dal-Hyun
Application Number:
JP2003556404A
Publication Date:
March 12, 2008
Filing Date:
December 27, 2002
Export Citation:
Assignee:
CJ Corp.
International Classes:
C07D213/71; C07D401/02; A61K31/444; A61P1/04; A61P5/24; A61P11/06; A61P15/00; A61P15/06; A61P19/10; A61P25/04; A61P25/28; A61P27/06; A61P29/00; A61P29/02; A61P35/00; A61P43/00
Domestic Patent References:
| JP11514008A | ||||
| JP2001517654A | ||||
| JP2003525288A | ||||
| JP2000509032A |
Other References:
PINTO, DONALD J. P.,Terphenyl cyclooxygenase-2 (COX-2) inhibitors: optimization of the central ring and o-biphenyl analogs,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,1999年,9(7), 919-924
KHANNA ISH K.,Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents,JOURNAL OF MEDICINAL CHEMISTRY,2000年,43(16), 3168 - 3185
HABEEB AMGAD G.,Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2(COX-2) inhibitors: Replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere,JOURNAL OF MEDICINAL CHEMISTRY,2001年,44(18),3039 - 3042
KHANNA ISH K.,Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents,JOURNAL OF MEDICINAL CHEMISTRY,2000年,43(16), 3168 - 3185
HABEEB AMGAD G.,Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2(COX-2) inhibitors: Replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere,JOURNAL OF MEDICINAL CHEMISTRY,2001年,44(18),3039 - 3042
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Furudate Kutanko
Yuriko Shinobu
Furudate Kutanko