The design of the stable heterodimer antibody which has mutation all over Fc domain

Title:

The design of the stable heterodimer antibody which has mutation all over Fc domain

Document Type and Number:

Japanese Patent JP6167040

Kind Code:

B2

Abstract:

The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) Fc molecule, and increased stability and purity of the resulting variant Fc heterodimers. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.

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Inventors:

Cabrera, Eric Escobar
Von Kleidenstein, Thomas Spreter
Dixit, Sulgit Bimalao
Lario, Paula Irene
Poon, David Kai Yuen
D'Angelo, Igor Edmond Paolo

Application Number:

JP2013536966A

Publication Date:

July 19, 2017

Filing Date:

November 04, 2011

Export Citation:

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Assignee:

Zym Works, Inc.

International Classes:

A61K39/395; C07K16/18; A61P35/00; A61P37/06; C12N1/15; C12N1/19; C12N1/21; C12N5/10

Domestic Patent References:

JP11500915A

Foreign References:

WO2009089004A1
WO2010085682A1

Other References:

Nature Bioechnol.,1998年,Vol.16,p677-681
J. Biol. Chem.,2010年,Vol.285,No.25,p19637-19646,Supplementary Tables

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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