Title:
ジアザスピロＲＯＣＫ阻害剤
Document Type and Number:
Japanese Patent JP7163385
Kind Code:
B2
Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Inventors:
Yehen Joo
Sunita Buoy Debunani
William Earl Ewing
Sunita Buoy Debunani
William Earl Ewing
Application Number:
JP2020524791A
Publication Date:
October 31, 2022
Filing Date:
November 01, 2018
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D471/10; A61K31/4178; A61K31/438; A61K31/444; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/496; A61K31/497; A61K31/498; A61K31/4985; A61K31/517; A61K31/519; A61K31/53; A61K31/5355; A61K31/536; A61K31/5377; A61K31/541; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P21/00; A61P25/00; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07D487/10; C07D519/00
Domestic Patent References:
| JP2019520396A | ||||
| JP2019520398A | ||||
| JP2013526526A | ||||
| JP2013526527A | ||||
| JP2012511012A |
Foreign References:
| WO2016112236A1 |
Attorney, Agent or Firm:
Yamato Kento
Shinagawa
Futami Kamahira
Masahiro Suwon
Wu Yingyan
Shinagawa
Futami Kamahira
Masahiro Suwon
Wu Yingyan