Title:
N,N-ジメチルイミドジカルボンイミド酸ジアミドのジカルボン酸塩、その製造方法、及びその薬剤学的組成物
Document Type and Number:
Japanese Patent JP5292404
Kind Code:
B2
Abstract:
Disclosed herein are a novel dicarboxylic acid salt of N,N-dimethylimidodicarbonimidic diamide, a preparation method thereof and a pharmaceutical composition comprising the same. More specifically, disclosed herein are a novel dicarboxylic acid salt of N,N-dimethylimidodicarbonimidic diamide, a crystalline acid addition salt prepared by allowing N,N-dimethylimidodicarbonimidic diamide to react with a specific dicarboxylic acid, which has improved physical and chemical properties including solubility, stability, non-hygroscopicity and anti-adhesive properties, and low toxicity, and thus is very effective in the prevention and treatment of not only diabetes and its complications in patients with so-called metabolic syndromes, in which diabetes, obesity, hyperlipidemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndromes, etc. appear in combination, but also p53 gene-deficient cancers, muscular pain, muscle cytotoxicity and rhabdomyolysis, as well as a preparation method thereof and a pharmaceutical composition comprising the same.
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Inventors:
Kim, Seung Wook
Jun, Seung Soo
Jo, Jung Kwan
Ko jason
Kim, Yun Eun
Kim Byungha
Kim, Duk
Jun, Seung Soo
Jo, Jung Kwan
Ko jason
Kim, Yun Eun
Kim Byungha
Kim, Duk
Application Number:
JP2010525765A
Publication Date:
September 18, 2013
Filing Date:
September 19, 2008
Export Citation:
Assignee:
HANALL BIOPHARMA CO.,LTD.
International Classes:
C07C279/26; C07C55/08; C07C277/08
Domestic Patent References:
| JP2001525361A | ||||
| JP2002506812A | ||||
| JP2002512953A |
Foreign References:
| WO2002012177A1 |
Attorney, Agent or Firm:
Ryu Iwatani