Title:
The directions for the antibody in the medical treatment or prevention of cell damage activity anti-LAG-3 monoclonal antibody, organ transplant refusal, and an autoimmune disease
Document Type and Number:
Japanese Patent JP6177735
Kind Code:
B2
Abstract:
The present invention concerns a molecule binding to LAG-3 protein and causing depletion of LAG-3 activated T cells, particularly said molecule is a cytotoxic anti-LAG-3 monoclonal antibody or fragment thereof. It also concerns a method of treating or preventing organ transplant rejection or autoimmune diseases in a mammal comprising administering to said mammal a therapeutically effective amount of said antibody.
Inventors:
Toribel, Frederick
Ban Orb, Bernard
Audebourg, Thomas
Ban Orb, Bernard
Audebourg, Thomas
Application Number:
JP2014154941A
Publication Date:
August 09, 2017
Filing Date:
July 30, 2014
Export Citation:
Assignee:
IMMUTEP
International Classes:
C07K16/28; A61K39/395; A61P29/00; A61P37/06
Domestic Patent References:
| JP2000508226A |
Other References:
Trends Mol. Med., 2004, 10(3), pp.130-135
Nat. Med., 2003, 9(10), pp.1275-1280
Mol. Cells, 2005, 20(1), pp.17-29
Nat. Med., 2003, 9(10), pp.1275-1280
Mol. Cells, 2005, 20(1), pp.17-29
Attorney, Agent or Firm:
Makoto Onda
Hironobu Onda
Atsushi Honda
Hironobu Onda
Atsushi Honda