Title:
新規なダンマランサポゲニン、抗癌剤としてのその使用方法及びその製造方法
Document Type and Number:
Japanese Patent JP2004537565
Kind Code:
A
Abstract:
This invention relates to a process for producing sapogenins and ginsenosides comprising the steps of mixing a ginsenoside extract with water, mixing the ginsenoside extract and water with an alkali-metal alcoholate solution or a hydroxide-ethanol solution to produce a mixture; or, alternatively, mixing a ginsenoside extract with ethanol, mixing the extract and ethanol with alkali-metal alcoholates solution to produce a mixture. The resultant mixture is placed in a reaction tank so that the resultant mixture can undergo chemical reactions under high temperature and high pressure effective to produce sapogenins therefrom. The temperature of the reaction tank can range between 150-300° C. and the pressure can range between 2.5 to 8.4 MPa. After the reaction is completed, an intermediate product of a mix of ginsenosides and sapogenins from the ethanol mixture is collected and the desired sapogenins and ginsenosides are separated from the intermediate product by silica-gel-column chromatography.
Inventors:
Huang, ton
Qi, Tong Feng
Qi, Tong Feng
Application Number:
JP2003515541A
Publication Date:
December 16, 2004
Filing Date:
July 24, 2002
Export Citation:
Assignee:
PANAGIN PHARMACEUTICALS INC.
International Classes:
A61K9/00; A61K31/575; A61K31/704; A61K36/25; A61P35/00; C07J9/00; C07J17/00; (IPC1-7): C07J9/00; A61K31/575; A61K31/704; A61K35/78; A61P35/00
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Makoto Onda