Title:
A discharge control type solid polymer nanoparticle
Document Type and Number:
Japanese Patent JP6118914
Kind Code:
B2
Abstract:
Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
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Inventors:
Birodot, Mark Tee.
Kadiyara, Sudakal
Cinde, Rajesh Earl.
White, Brian H.
Worcester, Richard
Birder, Timothy Edward
Morrow, Benoit
Kadiyara, Sudakal
Cinde, Rajesh Earl.
White, Brian H.
Worcester, Richard
Birder, Timothy Edward
Morrow, Benoit
Application Number:
JP2015550852A
Publication Date:
April 19, 2017
Filing Date:
December 30, 2013
Export Citation:
Assignee:
TARVEDA THERAPEUTICS,INC.
International Classes:
A61K47/50; A61K9/14; A61K31/282; A61K31/337; A61K31/70; A61K38/00; A61K45/00; A61K47/32; A61K47/34; A61K49/00; A61K51/00; A61P35/00; A61P35/02
Foreign References:
WO2012030745A1 |
Other References:
Mol. Pharm., 2012 Jun, Vol.9, No.6, p.1590-1598
Bioconjug. Chem., 2008, Vol.19, No.1, p.39-49
Bioconjug. Chem., 2008, Vol.19, No.1, p.39-49
Attorney, Agent or Firm:
Makoto Onda
Hironobu Onda
Atsushi Honda
Hironobu Onda
Atsushi Honda