A discharge control type solid polymer nanoparticle

Title:

A discharge control type solid polymer nanoparticle

Document Type and Number:

Japanese Patent JP6118914

Kind Code:

B2

Abstract:

Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

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Inventors:

Birodot, Mark Tee.
Kadiyara, Sudakal
Cinde, Rajesh Earl.
White, Brian H.
Worcester, Richard
Birder, Timothy Edward
Morrow, Benoit

Application Number:

JP2015550852A

Publication Date:

April 19, 2017

Filing Date:

December 30, 2013

Export Citation:

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Assignee:

TARVEDA THERAPEUTICS,INC.

International Classes:

A61K47/50; A61K9/14; A61K31/282; A61K31/337; A61K31/70; A61K38/00; A61K45/00; A61K47/32; A61K47/34; A61K49/00; A61K51/00; A61P35/00; A61P35/02

Foreign References:

WO2012030745A1

Other References:

Mol. Pharm., 2012 Jun, Vol.9, No.6, p.1590-1598
Bioconjug. Chem., 2008, Vol.19, No.1, p.39-49

Attorney, Agent or Firm:

Makoto Onda
Hironobu Onda
Atsushi Honda

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