Title:
A disease sample analysis apparatus, an analysis system, and an analysis method
Document Type and Number:
Japanese Patent JP6214016
Kind Code:
B2
Abstract:
[Problem] To elucidate a correlation between a disease and the amount of amino acid stereoisomers or the change in the amount by carrying out a total analysis of amino acid stereoisomers, leading to development of a novel method for diagnosing a disease, and a novel apparatus for diagnosing a disease in which the method for diagnosing a disease is executed.[Means for Resolution] The apparatus for analyzing a disease sample according to the present invention includes: a member for separating and quantitatively determining an amino acid stereoisomer in a biological material from a subject; a member for obtaining a disease state index value through a calculation by substituting the amount of the amino acid stereoisomer into a discriminant equation; and a member for outputting disease state information on the subject on the basis of the disease state index value. The discriminant equation may be: disease state index value = (a measurement value for an amino acid stereoisomer that correlates with the disease from among the measurement values in a biological material from the subject)/ (in a biological material from a reference value from a healthy individual), or the like. The method for analyzing a disease sample according to the present invention includes: a step of measuring the amount of amino acid stereoisomers in a biological material from a subject; a step of obtaining a disease state index value through a calculation by substituting the amount of the amino acid stereoisomers into a discriminant equation; and the like.
Inventors:
Kenji Hamase
Yousuke Tojo
Masashi Mita
Chieko Mizumoto
Yousuke Tojo
Masashi Mita
Chieko Mizumoto
Application Number:
JP2016209988A
Publication Date:
October 18, 2017
Filing Date:
October 26, 2016
Export Citation:
Assignee:
Kyushu University
Shiseido Co., Ltd.
Shiseido Co., Ltd.
International Classes:
G01N33/68; G01N33/48; G16B20/00
Domestic Patent References:
| JP2010281826A |
Foreign References:
| WO2004081527A2 | ||||
| US20110244486 | ||||
| US20110311650 |
Other References:
田坂仁正,高浸透圧性非ケトン性昏睡、糖尿病性ケトアシドーシスならびに乳酸アシドーシスの血漿アミノ酸動態,糖尿病,1981年,Vol.24 No.3,Page.389-394
湯澤由紀夫,生活習慣病とガスメッセンジャー,Therapeutic Research,Vol.33 No.2,2012年 2月20日,Vol.33 No.2,Page.207-208
MIN Jun Zhe,Determination of dl-amino acids, derivatized with R(-)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole, in nail of diabetic patients by UPLC-ESI-TOF-MS,J Chromatogr B,2011年11月 1日,Vol.879 No.29,Page.3220-3228
浜瀬健司,キラルアミノ酸のメタボロミクス,ファルマシア,2014年 4月 1日,Vol.50 No.4,Page.315-320
石田裕則,腎不全患者における血清中D‐アミノ酸動態に関する研究,北里医学,1993年 2月,Vol.23 No.1,Page.51-62
Young G A,D-Amino acids in chronic renal failure and the effects of dialysis and urinary losses,Amino acids,1994年10月,Vol. 6, No. 3,pp. 283-293
HAMASE K,D-Amino acids in mammals and their diagnostic value,J Chromatogr B,2002年12月 5日,Vol.781 No.1/2,Page.73-91
WALDHIER Magdalena C,Improved enantiomer resolution and quantification of free d-amino acids in serum and urine by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry,J Chromatogr A,2011年 7月15日,Vol.1218 No.28,Page.4537-4544
MIYOSHI Yurika,Simultaneous two-dimensional HPLC determination of free d-serine and d-alanine in the brain and periphery of mutant rats lacking d-amino-acid oxidase,J Chromatogr B,2011年11月 1日,Vol.879 No.29,Page.3184-3189
FUKUSHIMA T,Determination of D-Amino Acids in Serum from Patients with Renal Dysfunction,Biol Pharm Bull,1995年 8月,Vol.18 No.8,Page.1130-1132
D'Aniello A,Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release,FASEB journal : official publication of the Federation of American Societies for Experimental Biology,2000年 4月,Vol. 14, No. 5,pp.699-714
NISHIKAWA Toru,Metabolism and Functional Roles of Endogenous D-Serine in Mammalian Brains,Biol Pharm Bull,2005年,Vol.28 No.9,Page.1561-1565
BRUECKNER H,Gas chromatographic characterization of free D-amino acids in the blood serum of patients with renal disorders and of healthy volunteers,J Chromatogr,1993年 4月21日,Vol.614 No.1,Page.7-17
Zelezniak, Aleksej,Metabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes,PLoS Computational Biology[ISSN: 1553-7358],2010年,Vol.6 No.4,DOI 10.1371/journal.pcbi.1000729,URL,http://www.ploscompbiol.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pcbi.1000729&representation=PDF
MANNA Prasenjit,Hydrogen Sulfide and L-Cysteine Increase Phosphatidylinositol 3,4,5-Trisphosphate (PIP3) and Glucose Utilization by Inhibiting Phosphatase and Tensin Homolog (PTEN) Protein and Activating Phosphoinositide 3-Kinase (PI3K)/Serine/Threonine Protein Kinase (AKT)/Protein Kinase Cζ/λ (PKCζ/λ) in 3T3l1 Adipocytes,J Biol Chem,2011年11月18日,Vol.286 No.46,Page.39848-39859
湯澤由紀夫,生活習慣病とガスメッセンジャー,Therapeutic Research,Vol.33 No.2,2012年 2月20日,Vol.33 No.2,Page.207-208
MIN Jun Zhe,Determination of dl-amino acids, derivatized with R(-)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole, in nail of diabetic patients by UPLC-ESI-TOF-MS,J Chromatogr B,2011年11月 1日,Vol.879 No.29,Page.3220-3228
浜瀬健司,キラルアミノ酸のメタボロミクス,ファルマシア,2014年 4月 1日,Vol.50 No.4,Page.315-320
石田裕則,腎不全患者における血清中D‐アミノ酸動態に関する研究,北里医学,1993年 2月,Vol.23 No.1,Page.51-62
Young G A,D-Amino acids in chronic renal failure and the effects of dialysis and urinary losses,Amino acids,1994年10月,Vol. 6, No. 3,pp. 283-293
HAMASE K,D-Amino acids in mammals and their diagnostic value,J Chromatogr B,2002年12月 5日,Vol.781 No.1/2,Page.73-91
WALDHIER Magdalena C,Improved enantiomer resolution and quantification of free d-amino acids in serum and urine by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry,J Chromatogr A,2011年 7月15日,Vol.1218 No.28,Page.4537-4544
MIYOSHI Yurika,Simultaneous two-dimensional HPLC determination of free d-serine and d-alanine in the brain and periphery of mutant rats lacking d-amino-acid oxidase,J Chromatogr B,2011年11月 1日,Vol.879 No.29,Page.3184-3189
FUKUSHIMA T,Determination of D-Amino Acids in Serum from Patients with Renal Dysfunction,Biol Pharm Bull,1995年 8月,Vol.18 No.8,Page.1130-1132
D'Aniello A,Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release,FASEB journal : official publication of the Federation of American Societies for Experimental Biology,2000年 4月,Vol. 14, No. 5,pp.699-714
NISHIKAWA Toru,Metabolism and Functional Roles of Endogenous D-Serine in Mammalian Brains,Biol Pharm Bull,2005年,Vol.28 No.9,Page.1561-1565
BRUECKNER H,Gas chromatographic characterization of free D-amino acids in the blood serum of patients with renal disorders and of healthy volunteers,J Chromatogr,1993年 4月21日,Vol.614 No.1,Page.7-17
Zelezniak, Aleksej,Metabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes,PLoS Computational Biology[ISSN: 1553-7358],2010年,Vol.6 No.4,DOI 10.1371/journal.pcbi.1000729,URL,http://www.ploscompbiol.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pcbi.1000729&representation=PDF
MANNA Prasenjit,Hydrogen Sulfide and L-Cysteine Increase Phosphatidylinositol 3,4,5-Trisphosphate (PIP3) and Glucose Utilization by Inhibiting Phosphatase and Tensin Homolog (PTEN) Protein and Activating Phosphoinositide 3-Kinase (PI3K)/Serine/Threonine Protein Kinase (AKT)/Protein Kinase Cζ/λ (PKCζ/λ) in 3T3l1 Adipocytes,J Biol Chem,2011年11月18日,Vol.286 No.46,Page.39848-39859
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Hidena Tsuda
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Hidena Tsuda
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