Title:
虚血性心疾患の細胞治療で使用するためのeNOS転写エンハンサー
Document Type and Number:
Japanese Patent JP2007509873
Kind Code:
A
Abstract:
The present invention relates to the use of compounds which enhance the transcription of endothelial nitric oxide synthase (eNOS) for treating stem and progenitor cells in the cell therapy of patients with ischemic heart diseases such as coronary heart disease or ischemic cardiomyopathy. Treatment of such cells which are isolated from bone marrow, for example, with an eNOS transcription enhancer prior to their administration improves their functional activity and ameliorates neovascularization of the heart and cardiac regeneration.
Inventors:
Andreas Tsaiher
Stephanie Dimmerer
Christopher Haschen
Hartmut Rutten
Stephanie Dimmerer
Christopher Haschen
Hartmut Rutten
Application Number:
JP2006537141A
Publication Date:
April 19, 2007
Filing Date:
October 22, 2004
Export Citation:
Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
A61K35/12; A61K31/00; A61K31/167; A61K31/18; A61K31/277; A61K31/401; A61K31/44; A61K31/445; A61K31/537; A61K31/54; A61K35/28; A61P9/04; A61P9/10; C12N5/07; C12N5/074; C12N5/0775; C12N5/0789
Domestic Patent References:
| JP2002540176A | 2002-11-26 |
Foreign References:
| WO2002064146A1 | 2002-08-22 |
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa