Title:
エダラボン塩
Document Type and Number:
Japanese Patent JP7152122
Kind Code:
B2
Abstract:
The invention relates to a salt of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone), wherein the salt is 3-methyl-1-phenyl-2-pyrazolin-5-one napadisylate or 3-methyl-1-phenyl-2-pyrazolin-5-one hemi-napadisylate. These napadisylate salts of edaravone are easy to manufacture and dissolve more rapidly in water than the free edaravone base. In addition, the edaravone salts of the present invention are very stable and easy to handle.The invention also relates to a pharmaceutical composition comprising the aforementioned edaravone salt and to a method of preparing such edaravone salt.
Inventors:
Fernandez Casares, Ana
Van der Haste, Ronald
Morener, Shitsuke Haiku
Van der Haste, Ronald
Morener, Shitsuke Haiku
Application Number:
JP2020520823A
Publication Date:
October 12, 2022
Filing Date:
October 12, 2018
Export Citation:
Assignee:
Treeway TW001 B.V.
International Classes:
C07D231/26; A61K9/08; A61K9/14; A61K9/20; A61K9/48; A61K31/4152; A61P9/10; A61P25/28; A61P37/06
Domestic Patent References:
| JP2006052172A | ||||
| JP2010518038A |
Foreign References:
| CN103483262A | ||||
| WO2003024445A1 |
Other References:
Monatsh. Chem.,2013年,Vol.144, No.9,pp.1335-1349
Attorney, Agent or Firm:
Ikeda Adult
Junichiro Sakamaki
Masakazu Noda
Junichiro Sakamaki
Masakazu Noda