Title:
An efficient nanoparticle type 2 chain oligo RNA structure and a manufacturing method for the same
Document Type and Number:
Japanese Patent JP6060178
Kind Code:
B2
Abstract:
Provided are a double-stranded oligo RNA structure and a method of preparing the same, and more specifically, a double-stranded oligo RNA structure in which a polymer compound is covalently bound to a double-stranded oligo RNA in order to improve stability in vivo and a cell delivery efficiency of the double-stranded oligo RNA, and a method of preparing the same. The double-stranded oligo RNA structure having the optimized structure according to the present invention may not inhibit functions of the double-stranded oligo RNA, but effectively improve stability and cell membrane permeability of the double-stranded oligo RNA, such that the double-stranded oligo RNA may be delivered into the cell even at a low concentration dosage thereof to be significantly used as a tool for treatment of cancer, infectious diseases, and the like, as well as a new delivery system of the double-stranded oligo RNA.
Inventors:
Jejeuk
Hamboram
Kim Hannah
Park Hano
Hamboram
Kim Hannah
Park Hano
Application Number:
JP2014551188A
Publication Date:
January 18, 2017
Filing Date:
January 04, 2013
Export Citation:
Assignee:
BIONEER CORPORATION
International Classes:
C12N15/113; A61K31/713; A61K48/00; A61P31/00; A61P35/00
Domestic Patent References:
| JP5758381B2 |
Foreign References:
| CA2761749A1 |
Other References:
RIVAS, Fabiola V. et al.,"Purified Argonaute2 and an siRNA form recombinant human RISC",Nat. Struct. Mol. Biol.,2005年,Vol. 12,P. 340-349
Attorney, Agent or Firm:
Kenichi Morita
Kenjiro Yamaguchi
Hironori Nagayama
Yuzaki Ozaki
Kenjiro Yamaguchi
Hironori Nagayama
Yuzaki Ozaki
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