Title:
エナンチオマーおよび/またはジアステレオマーに富むエステル、チオエステル、アルコール、またはチオールの製造方法
Document Type and Number:
Japanese Patent JP2011502471
Kind Code:
A
Abstract:
The invention relates to a process for preparing an enantiomerically and/or diastereomerically enriched ester or thioester having at least two adjacent chiral centres, wherein a mixture of stereoisomers of a secondary alcohol or thiol having a structure comprising a first chiral center forming a secondary alcohol or secondary thiol moiety in the beta position relative to a second chiral center having one hydrogen substituent, is reacted with an acyl donor in the presence of an epimerisation catalyst and a stereoselective acylation catalyst.
Inventors:
Vergier, Geraldus, Charles, Maria
Quaet Friev, Peter, Jan, Leonard, Mario
Brock Sterman, Quirinus, Bernardus
Quaet Friev, Peter, Jan, Leonard, Mario
Brock Sterman, Quirinus, Bernardus
Application Number:
JP2010529379A
Publication Date:
January 27, 2011
Filing Date:
October 15, 2008
Export Citation:
Assignee:
DSM IP ASSETS B.V.
International Classes:
C12P13/00; A61K8/42; A61K31/165; C07B57/00; C07C67/03; C07C69/24; C07C209/68; C07C219/24; C07C231/16; C07C233/06; C12P41/00; A61K8/37; A61K8/41; A61K31/215; C07B61/00; C07C29/143; C07C35/08
Other References:
JPN6012038686; Ｊ Ａｍ Ｃｈｅｍ Ｓｏｃ．， １９９９年， 第１２１巻， １６４５-１６５０ページ
JPN6012038688; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔ．， １９９９年， 第４０巻， ６２８１-６２８４ページ
JPN6012038690; 化学， ２００４年， 第５９巻， ６６-６７ページ
JPN6012038691; Ｊ Ａｍ Ｃｈｅｍ Ｓｏｃ．， １９９８年， 第１２０巻， ７４７９-７４８３ページ
JPN6012038694; Ｔｅｔｒａｈｅｄｒｏｎ Ａｓｙｍｍｅｔｒｙ， ２００４年， 第１５巻， １３３５-１３４１ページ
JPN6012038688; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔ．， １９９９年， 第４０巻， ６２８１-６２８４ページ
JPN6012038690; 化学， ２００４年， 第５９巻， ６６-６７ページ
JPN6012038691; Ｊ Ａｍ Ｃｈｅｍ Ｓｏｃ．， １９９８年， 第１２０巻， ７４７９-７４８３ページ
JPN6012038694; Ｔｅｔｒａｈｅｄｒｏｎ Ａｓｙｍｍｅｔｒｙ， ２００４年， 第１５巻， １３３５-１３４１ページ
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Yoshinori Shimizu
Ikeda adult
Masakazu Noda
Yoshinori Shimizu
Ikeda adult