Title:
【発明の名称】環状アミン誘導体
Document Type and Number:
Japanese Patent JP3078244
Kind Code:
B2
Abstract:
Cyclic amine cpds. of formula (I) and their salts are new. - J is (a) a gp., opt. substd., of: phenyl, pyridyl, pyrazyl, cyclohexyl, quino(xa)lyl or furyl; (b) a monovalent or divalent gp., where the phenyl may have substit(s), of: indan(ol)yl, (iii) inden(on)yl, indan(edio)hyl, tetralonyl, benzosuberonyl, or C6H5-CO-CH(CH3)-; (c) a monovalent gp. derived from a cyclic amide cpd. (d) lower alkyl; or (e) R21-CH=CH- (R21 = H or (lower alkoxycarbonyl). B = (CHR22)r, CO(CHR22)r, NR4-(HCR22)r, CO-NR5-(CHR22)r, CH=CH-(CHR22)r, OCOO-(CHR22)r, OOC-NH-(CHR22)r, NH-CO-(CHR32)4, CH2CONH-(CHR22)r, (CH2)2CONH-(CHR22)r, CH(OH)-(CHR22)r, CH(OH)-(CHR22)r, = (CH-CH=CH)b, =CH-(CH2)c, =(CH-CH)d, COCH=CH-CH2, COCH2-CH(CH(OH)CH2, CH(CH3)CONHCH2, CH=CHCONH(CH2)2, NH, O, S, dialkylaminoalkylcarbonyl or lower alkoxycarbonyl; R4 = H, acyl, lower alkyl(sulphonyl), (substd.)phenyl, or (substd.)benzyl; R5 = H, lower alkyl or phenyl, r = 0-10; R22 = H or Me such that one alkylene may have no CH3 or one or more CH3; b = 1-3; c = 0-9; d = 0-5; T = N or C (i) Q = N, C or (i) q = 1-3; K = H, (substd.) phenyl, arylalkyl in which the phenyl may be substd. cinnamyl, lower alkyl, pyridylmethyl, cyclo(alkyl)alkyl, adamantanemethyl, furylmethyl, lower alkoxycarbonyl or acyl; and dotted lines is a single-or double-bond. - 1-benzyl-4-((5,6-dimethoxy -1-indanon)- 2-ylidenyl)methyl) piperidine hydrochlorideis and example.
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Inventors:
Hachiro Sugimoto
Yutaka Tsuchiya
Kunizo Higurashi
Norio Kanabe
Youichi Iimura
Atsushi Sasaki
Yoshiharu Shanxi
Hiroo Ogura
Shin Araki
Takashi Ozasa
Atsuhiko Kubota
Michiko Ozasa
Kiyomi Yamatsu
Yutaka Tsuchiya
Kunizo Higurashi
Norio Kanabe
Youichi Iimura
Atsushi Sasaki
Yoshiharu Shanxi
Hiroo Ogura
Shin Araki
Takashi Ozasa
Atsuhiko Kubota
Michiko Ozasa
Kiyomi Yamatsu
Application Number:
JP18630697A
Publication Date:
August 21, 2000
Filing Date:
July 11, 1997
Export Citation:
Assignee:
Eisai Co., Ltd.
International Classes:
A61K31/40; A61K31/395; A61K31/4427; A61K31/443; A61K31/4433; A61K31/445; A61K31/4465; A61K31/451; A61K31/452; A61K31/47; A61K31/495; A61K31/50; A61K31/505; A61K31/55; A61P21/00; A61P25/02; A61P25/28; A61P43/00; C07D207/06; C07D207/09; C07D209/32; C07D211/08; C07D211/10; C07D211/18; C07D211/22; C07D211/26; C07D211/28; C07D211/30; C07D211/32; C07D211/34; C07D211/44; C07D211/70; C07D211/74; C07D211/76; C07D211/94; C07D213/24; C07D213/81; C07D215/16; C07D217/04; C07D217/24; C07D223/16; C07D235/26; C07D239/80; C07D241/24; C07D243/14; C07D243/38; C07D295/10; C07D295/12; C07D295/22; C07D307/68; C07D401/04; C07D401/06; C07D401/12; C07D405/04; C07D405/06; C07D405/12; C07D409/06; C07D413/06; C07D471/04; C07D471/06; C07D; (IPC1-7): C07D207/09; A61K31/40; A61K31/445; A61K31/47; A61K31/495; A61K31/505; A61K31/55; A61P25/28; A61P43/00; C07D211/22; C07D211/26; C07D211/32; C07D211/34; C07D295/10; C07D401/06; C07D401/12; C07D405/04; C07D405/06; C07D405/12; C07D471/04
Domestic Patent References:
| JP52122378A | ||||
| JP52122379A | ||||
| JP5377069A | ||||
| JP5387365A | ||||
| JP5390267A | ||||
| JP5392783A | ||||
| JP406347B1 |
Attorney, Agent or Firm:
Kaoru Furuya (3 outside)