Title:
A flavonoid compound and directions for use for the same
Document Type and Number:
Japanese Patent JP6122431
Kind Code:
B2
Abstract:
There is provided now flavonoid compounds, compositions containing these compounds, methods for their synthesis, and uses of these compounds. In particular, there is provided methods of preventing and or mitigating the damage caused by cell apoptosis or cell necrosis by administration of the novel flavonoid compounds. In some aspects, there is provided methods for inhibiting pro-apoptotic signalling kinases activity in a subject while regulating and activating extracelluar signal regulated kinase (ERK).
Inventors:
McLachlan, Grant
Application Number:
JP2014524226A
Publication Date:
April 26, 2017
Filing Date:
August 13, 2012
Export Citation:
Assignee:
Armoron Bio Pty Limited
International Classes:
C07D215/233; A61K31/352; A61K31/382; A61K31/4025; A61K31/436; A61K31/47; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P25/06; A61P39/00; A61P43/00; C07D215/38; C07D311/62; C07D335/06; C07D491/052
Domestic Patent References:
| JP2011513342A | ||||
| JP2007051099A | ||||
| JP2003313182A | ||||
| JP2003531899A | ||||
| JP2002523501A | ||||
| JP2011512354A | ||||
| JP2004123728A |
Foreign References:
| AU2006233256A1 |
Other References:
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Mattarei, Andrea 他,Regioselective O-derivatization of quercetin via formation of ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative,Molecules,2010年,15,4722-4736
Li, Ning; Shao, Li; Zhang, Chao-Feng; Zhang, Mian,Two new flavonoid alkaloids from Senecio argunensis,Journal of Asian Natural Products Research ,2008年,10(12),1143-1146
Howell, Hiten 他,Identification of two novel promelacacinidin dimers from Acacia nigrescens,Journal of Natural Products,2002年,65(5),769-771
Ito, Chihiro 他,A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity,Journal of Natural Products,1999年,62(12),1668-1671
Picq, Madeleine 他,Pentasubstituted quercetin analogs as selective inhibitors of particulate 3',5'-cyclic-AMP phosphodiesterase from rat brain,Journal of Medicinal Chemistry,1982年,25(10),1192-1198
Enriquez, Philip M.,Novel cobalt (II) complexes as catalysts for redox-couple amplification processes,Research Disclosure,1977年,15541,93-94
REGISTRY(STN)[online],2010.03.19[検索日 2015.11.16]CAS登録番号 1211594-00-1
REGISTRY(STN)[online],2010.03.19[検索日 2015.11.16]CAS登録番号 1211593-18-8
Mattarei, Andrea 他,A mitochondriotropic derivative of quercetin: a strategy to increase the effectiveness of polyphenols,ChemBioChem,2008年,9(16),2633-2642
Qin, Cheng Xue 他,Understanding the Cardioprotective Effects of Flavonols: Discovery of Relaxant Flavonols without Antioxidant Activity,Journal of Medicinal Chemistry,2008年,51(6),1874-1884
Takechi, Atsushi; Takikawa, Hirosato; Miyake, Hideyoshi; Sasaki, Mitsuru,Synthesis of 3-aminoflavones from 3-hydroxyflavones via 3-tosyloxy- or 3-mesyloxyflavones,Chemistry Letters,2006年,35(1),128-129
REGISTRY(STN)[online],2010.03.19[検索日 2015.11.16]CAS登録番号 1211593-31-5
REGISTRY(STN)[online],2010.03.19[検索日 2015.11.16]CAS登録番号 1211592-80-1
REGISTRY(STN)[online],2008.06.08[検索日 2015.11.16]CAS登録番号 1026343-74-7
REGISTRY(STN)[online],2010.05.13[検索日 2015.11.16]CAS登録番号 1222705-48-7
REGISTRY(STN)[online],2010.03.19[検索日 2015.11.16]CAS登録番号 1211595-53-7
Lee, Jinho; Park, Taesik; Jeong, Shinwu; Kim, Kyoung-Hee; Hong, Changyong,3-Hydroxychromones as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation,Bioorganic & Medicinal Chemistry Letters,2007年,17(5),1284-1287
Mattarei, Andrea 他,Regioselective O-derivatization of quercetin via formation of ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative,Molecules,2010年,15,4722-4736
Li, Ning; Shao, Li; Zhang, Chao-Feng; Zhang, Mian,Two new flavonoid alkaloids from Senecio argunensis,Journal of Asian Natural Products Research ,2008年,10(12),1143-1146
Howell, Hiten 他,Identification of two novel promelacacinidin dimers from Acacia nigrescens,Journal of Natural Products,2002年,65(5),769-771
Ito, Chihiro 他,A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity,Journal of Natural Products,1999年,62(12),1668-1671
Picq, Madeleine 他,Pentasubstituted quercetin analogs as selective inhibitors of particulate 3',5'-cyclic-AMP phosphodiesterase from rat brain,Journal of Medicinal Chemistry,1982年,25(10),1192-1198
Enriquez, Philip M.,Novel cobalt (II) complexes as catalysts for redox-couple amplification processes,Research Disclosure,1977年,15541,93-94
REGISTRY(STN)[online],2010.03.19[検索日 2015.11.16]CAS登録番号 1211594-00-1
REGISTRY(STN)[online],2010.03.19[検索日 2015.11.16]CAS登録番号 1211593-18-8
Mattarei, Andrea 他,A mitochondriotropic derivative of quercetin: a strategy to increase the effectiveness of polyphenols,ChemBioChem,2008年,9(16),2633-2642
Qin, Cheng Xue 他,Understanding the Cardioprotective Effects of Flavonols: Discovery of Relaxant Flavonols without Antioxidant Activity,Journal of Medicinal Chemistry,2008年,51(6),1874-1884
Takechi, Atsushi; Takikawa, Hirosato; Miyake, Hideyoshi; Sasaki, Mitsuru,Synthesis of 3-aminoflavones from 3-hydroxyflavones via 3-tosyloxy- or 3-mesyloxyflavones,Chemistry Letters,2006年,35(1),128-129
REGISTRY(STN)[online],2010.03.19[検索日 2015.11.16]CAS登録番号 1211593-31-5
REGISTRY(STN)[online],2010.03.19[検索日 2015.11.16]CAS登録番号 1211592-80-1
REGISTRY(STN)[online],2008.06.08[検索日 2015.11.16]CAS登録番号 1026343-74-7
REGISTRY(STN)[online],2010.05.13[検索日 2015.11.16]CAS登録番号 1222705-48-7
REGISTRY(STN)[online],2010.03.19[検索日 2015.11.16]CAS登録番号 1211595-53-7
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Atsushi Ohara
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Atsushi Ohara