Title:
新生糖ランダム化及びジギトキシン類似体
Document Type and Number:
Japanese Patent JP5065019
Kind Code:
B2
Abstract:
The present invention provides methods of producing compounds with enhanced desirable properties and diminished side effects as well as the compounds produced by the methods. In preferred embodiments, methods of the present invention use a universal chemical glycosylation method that employs reducing sugars and requires no protection or activation. In a preferred embodiment, the invention provides neoglycoside digitoxin analogs that include compounds with significantly enhanced cytotoxic potency toward human cancer cells and tumor-specificity, but are less potent Na+/K+-ATPase inhibitors in a human cell line than digitoxin.
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Inventors:
Thorson, John S.
Langenan, Joseph Em.
Langenan, Joseph Em.
Application Number:
JP2007518317A
Publication Date:
October 31, 2012
Filing Date:
June 24, 2005
Export Citation:
Assignee:
Wisconsin Alumni Research Foundation
International Classes:
C07J17/00; A61K31/704; A61P35/00
Domestic Patent References:
| JP59082096A |
Other References:
OBC,2003年,Vol.1,p.3059-3063
PERI F,TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHERS,1998年10月 1日,V54,P12269-12278
Anti-cancer Drugs,2001年,Vol.12,pp.475-483
PERI F,TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHERS,1998年10月 1日,V54,P12269-12278
Anti-cancer Drugs,2001年,Vol.12,pp.475-483
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura