Title:
カルボキシフラーレンおよびその使用方法
Document Type and Number:
Japanese Patent JP2005538935
Kind Code:
A
Abstract:
The instant invention is a method for increasing a metazoan's lifespan, comprising administering a carboxylated derivative of a C60 fullerene. The instant invention further is a process for extending a metazoan's lifespan by administering a superoxide dismutase-mimetic as well as a composition comprising a superoxide dismutase-mimetic. Further, the instant invention comprises a pharmaceutical composition comprising carboxyfullerenes having x pairs of adjacent carbon atoms bonded to two carbons of the C60 sphere wherein said adjacent carbon atom is further bonded to two groups of the general formula -COOH and -R, wherein R is independently selected from the group consisting of -COOH and -H, and wherein x is at least 1. A further embodiment is a non-metal containing composition which can catalytically eliminate two biologically reactive species. Another embodiment is a method of enhancing elimination of reactive oxygen species in eukaryotic cells by contacting cells with a superoxide dismutase mimetic.
Inventors:
Dougan, Laura El
Labetto, Eva Gee
Kuitku, Kevin El
Hard, joy
Labetto, Eva Gee
Kuitku, Kevin El
Hard, joy
Application Number:
JP2003571482A
Publication Date:
December 22, 2005
Filing Date:
February 20, 2003
Export Citation:
Assignee:
Washington University School of Medicine
International Classes:
A61K45/00; A61K31/19; A61K31/194; A61P39/06; A61P43/00; C01B31/02; C07C61/39; (IPC1-7): A61K31/194; A61K45/00; A61P39/06; A61P43/00
Domestic Patent References:
| JP2000514412A | 2000-10-31 | |||
| JPH01316328A | 1989-12-21 | |||
| JP2001097888A | 2001-04-10 |
Foreign References:
| US6265443B1 | 2001-07-24 | |||
| US5648523A | 1997-07-15 | |||
| WO2001089542A2 | 2001-11-29 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura