Title:
TGF-βII型受容体の2つのTGF-β結合ドメインを含有する融合タンパク質
Document Type and Number:
Japanese Patent JP2010529859
Kind Code:
A
Abstract:
The disclosure provides fusion proteins that contain two TGF-β binding domains of TGF-β type II receptor joined to each other by a linker. For example, the C terminus of the first TGF-β binding domain is joined by a short peptide linker (e.g., a 9-glycine linker) to the N terminus of the second TGF-β binding domain. Despite the proximity of the C terminus of the first domain to N terminus of the second domain, such a fusion protein effectively neutralizes TGF-β, in some cases, similarly to anti-TGF-β antibodies.
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Inventors:
Kiu farway
Red Better Stephen Earl.
Kyostio-Moore Sirkka
Red Better Stephen Earl.
Kyostio-Moore Sirkka
Application Number:
JP2010512388A
Publication Date:
September 02, 2010
Filing Date:
June 13, 2008
Export Citation:
Assignee:
GENZYME CORPORATION
International Classes:
C12N15/09; A61K38/22; A61K48/00; A61P1/16; A61P9/10; A61P11/00; A61P13/12; A61P17/00; A61P17/02; A61P19/04; A61P25/00; A61P35/00; C07K14/71; C07K19/00; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto