Title:
抗菌薬としての金（Ｉ）−ホスフィン化合物
Document Type and Number:
Japanese Patent JP2017519817
Kind Code:
A
Abstract:
細菌感染の予防または治療における使用のための式（Ｉ）【化１】の化合物（式中、ＲP1は、メチル、エチル、イソプロピル、シクロヘキシルまたはフェニルのいずれかであり、ＲP2は、メチル、エチル、イソプロピル、シクロヘキシル及びフェニルから選択され、ＲP3は、エチル、イソプロピル、シクロヘキシル、フェニルまたはピリジルのいずれかであり、Ａは、ＳまたはＳｅのいずれかであり、ＲAは、【化２】から選択され、式中、Ｙ1、Ｙ2、Ｙ3、Ｙ4及びＹ9は各々独立してＣＨまたはＮから選択され、式中、Ｙ1、Ｙ2、Ｙ3、Ｙ4及びＹ9のうちの少なくとも３つはＣＨであり、Ｖは、Ｏ、ＣＨ−ＯＲ01、Ｎ−ＣＯ2−ＲC2またはＮ−ＲN2から選択され、Ｙ5、Ｙ6、Ｙ7及びＹ8のうちの１つはＣＨ及びＮから選択され、かつその他はＣＨであり、Ｘは、ＮＨ、ＳまたはＯから選択され、ＲC1はＯ−ＲO2またはＮＨＲN1から選択され、ＲO1はＨ及びＣ1〜3非分枝アルキルから選択され、ＲO2はＣ1〜3非分枝アルキルであり、ＲN1はＨ及びＣ1〜3非分枝アルキルから選択され、ＲN2はＣ1〜3非分枝アルキルであり、ＲC2は、Ｃ1〜3非分枝アルキルまたはＣ3〜4分枝アルキルのいずれかであり、ＲC3は、Ｃ1〜3非分枝アルキル及びＣ2Ｈ4ＣＯ2Ｈから選択され、ＲC4はＨまたはＭｅのいずれかであり、ＲC5は、ＨまたはＭｅのいずれかであり、ＲC6は、１つ以上の任意のメチル置換基を表し、かつｎは２〜８の整数である）。
Inventors:
Ian Holmes
Alan Naylor
Gabriel Negoita-Giras
Jonathan Powell
Ian Charles
Dagmar Alber
Alan Naylor
Gabriel Negoita-Giras
Jonathan Powell
Ian Charles
Dagmar Alber
Application Number:
JP2017514984A
Publication Date:
July 20, 2017
Filing Date:
May 28, 2015
Export Citation:
Assignee:
AUSPHERIX LIMITED
International Classes:
C07F19/00; A61K31/66; A61K31/665; A61K31/675; A61L27/54; A61L31/16; A61P31/04; C12N1/20
Domestic Patent References:
| JPS5041859A | 1975-04-16 |
Foreign References:
| WO1995014703A1 | 1995-06-01 |
Other References:
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"Synthesis, single crystal X-ray analysis, and TEM for a single-sized Au11 cluster stabilized by", JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 691(4), JPN6018052171, 2006, pages 638-642
"Exploration on Au(S-4-py)PR3 complexes as a viable building block for constructing hetero-nuclea", JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 690(1), JPN6018052172, 2005, pages 48-56
"Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination c", JOURNAL OF MEDICINAL CHEMISTRY, vol. 29(2), JPN6018052174, 1986, pages 218-23
"Mechanistic studies of reactions of benzenethiol with methyl derivatives of platinum(II) and gol", JOURNAL OF THE CHEMICAL SOCIETY, DALTON TRANSACTIONS: INORGANIC CHEMISTRY (1972-1999), vol. (2), JPN6018052176, 1975, pages 115-20
"Antiarthritic activity in rats of some phosphinegold(I) thionucleobases and related thiolates", METAL-BASED DRUGS, vol. 5(4), JPN6018052177, 1998, pages 245-249
"Gold complexes with heterocyclic thiones as ligands. X-ray structure determination of [Au(C5H5N", JOURNAL OF THE CHEMICAL SOCIETY, DALTON TRANSACTIONS: INORGANIC CHEMISTRY (1972-1999), vol. (11), JPN6018052178, 1990, pages 3457-63
"A Gold(I) Mononuclear Complex and Its Association into Binuclear and Cluster Compounds by Hydrog", INORGANIC CHEMISTRY, vol. 39(24), JPN6018052179, 2000, pages 5520-5529
Attorney, Agent or Firm:
Axis International Patent Business Corporation