Title:
POPULATION OF NATURAL KILLER CELLS CULTURED EX VIVO
Document Type and Number:
Japanese Patent JP2016187341
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide population of natural killer (NK) cells cultured ex vivo.SOLUTION: The population is obtained by culturing a population of cells comprising NK cells with at least one growth factor and an effective concentration, effective exposure time and effective duration of exposure of nicotinamide and/or other nicotinamide moiety, wherein culturing the NK cells with the at least one growth factor and the effective concentration, effective exposure time and effective duration of exposure of the nicotinamide and/or other nicotinamide moiety results in at least one of the following: elevated expression of CD62L, elevated migration response, elevated homing and in vivo retention, greater proliferation and increased cytotoxic activity.SELECTED DRAWING: None
Inventors:
PELED TONY
GABI M FREI
GABI M FREI
Application Number:
JP2016102993A
Publication Date:
November 04, 2016
Filing Date:
May 24, 2016
Export Citation:
Assignee:
GAMIDA CELL LTD
International Classes:
C12N5/0783; A61K35/17; A61P31/12; A61P35/02; A61P37/02; A61P37/06; A61P43/00
Domestic Patent References:
| JP2008518945A | 2008-06-05 | |||
| JP2009517078A | 2009-04-30 |
Other References:
THE JOURNAL OF IMMUNOLOGY, vol. 162, JPN6015007930, 1999, pages 7376-7382
Attorney, Agent or Firm:
Nobuaki Kazehaya
Noriko Asano
Noriko Asano