Title:
CHO CELL EXPRESSED HET IL-15
Document Type and Number:
Japanese Patent JP2023145622
Kind Code:
A
Abstract:
To provide IL-15/IL-15Rα heterodimers produced in a CHO cell line, and methods of producing the heterodimers and methods of treatment using the heterodimers.SOLUTION: A polypeptide complex comprises a human interleukin 15 (IL-15) polypeptide and a human interleukin 15 receptor α (IL-15Rα) polypeptide. The polypeptide complex comprises N-linked glycans comprising FA2G2, FA2G2S1, FA2G2S2, FA3G3S1, FA2F1G2S2, FA3G2S2, and FA3G3S3.SELECTED DRAWING: None
Inventors:
RICHARD GABRIEL
THOMAS JOSTOCK
JUSTYNA JOZEFCZUK
URS ULRICH LOHRIG
ALEXANDRE AURELIEN PONS
THOMAS JOSTOCK
JUSTYNA JOZEFCZUK
URS ULRICH LOHRIG
ALEXANDRE AURELIEN PONS
Application Number:
JP2023122933A
Publication Date:
October 11, 2023
Filing Date:
July 28, 2023
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
C07K14/54; A61K38/16; A61K38/20; A61P35/00; C07K14/715; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Wataru Ueda
Eiji Katayama
Norio Omori
Wataru Ueda
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