Title:
【発明の名称】ベンゾヘテロ環化合物
Document Type and Number:
Japanese Patent JPH0776214
Kind Code:
B2
Abstract:
Novel benzoheterocyclic compounds of formula (I), wherein R<1> is H, halogen, alkyl, optionally substituted amino, alkoxy; R<2> is H, halogen, alkoxy, phenylalkoxy, OH, alkyl, optionally substituted amino, carbamoyl-alkoxy, optionally substituted amino-alkoxy, optionally substituted benzoyloxy; R<3> is a group: -NR<4>R<5> or -CO-NR<11>R<12>; R<4> is H, optionally substituted benzoyl, alkyl; R<5> is a group alpha [R<16> is halogen, optionally substituted alkyl, OH, alkoxy, alkanoyloxy, alkylthio, alkanoyl, carboxy, alkoxycarbonyl, CN, NO2, optionally substituted amino, phenyl, cycloalkyl, etc., or a group: -O-A-NR<6>R<7>; m is 0 to 3], phenyl-alkoxycarbonyl, alkanoyl, phenyl-alkanoyl, etc.; R<11> is H or alkyl; R<12> is cycloalkyl or optionally substituted phenyl; and W is a group: -(CH2)p (p is 3 to 5) or -CH=CH-(CH2)q (q is 1 to 3), the carbon atom of these groups being optionally replaced by 0, S, SO, SO2 or a group: -N(R<13>)- and further these groups having optionally 1 to 3 substituents of alkyl, alkoxycarbonyl, carboxy, OH, O, alkanoyloxy, etc., which have excellent vasopressin antagonistic activies and are useful as vasodilator, hypotensive agent, water diuretics, platelet agglutination inhibitor, and a vasopressin antagonistic composition containing the compound as the active ingredient.
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Inventors:
Hidenori Ogawa
Miyamoto Hisashi
Kondo glance
Hiroshi Yamashita
Kenya Nakaya
Komatsu Hajime
Riki Tanaka
Shinya Takara
Tominaga Michiaki
Youichi Yabuuchi
Miyamoto Hisashi
Kondo glance
Hiroshi Yamashita
Kenya Nakaya
Komatsu Hajime
Riki Tanaka
Shinya Takara
Tominaga Michiaki
Youichi Yabuuchi
Application Number:
JP28256890A
Publication Date:
August 16, 1995
Filing Date:
October 19, 1990
Export Citation:
Assignee:
Otsuka Pharmaceutical Co., Ltd.
International Classes:
C07D243/12; A61K31/395; A61K31/47; A61K31/495; A61K31/535; A61K31/538; A61K31/54; A61K31/5415; A61K31/55; A61K31/551; A61K31/554; A61P1/16; A61P3/00; A61P3/08; A61P7/02; A61P7/10; A61P9/00; A61P9/08; A61P9/12; A61P13/02; A61P15/00; C07D215/08; C07D215/12; C07D215/14; C07D215/20; C07D215/22; C07D215/233; C07D215/38; C07D215/42; C07D215/54; C07D223/16; C07D225/06; C07D241/42; C07D243/14; C07D245/06; C07D265/36; C07D267/14; C07D279/16; C07D281/10; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D491/04; C07D491/044; C07D491/10; C07D491/107; C07D498/04; (IPC1-7): C07D215/08; A61K31/47; A61K31/495; A61K31/535; A61K31/54; A61K31/55; C07D215/22; C07D215/38; C07D215/42; C07D223/16; C07D225/06; C07D241/42; C07D243/12; C07D243/14; C07D245/06; C07D265/36; C07D267/14; C07D279/16; C07D281/10; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D491/044; C07D491/107; C07D498/04
Attorney, Agent or Firm:
Eiji Saegusa (2 others)
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