Title:
The heterocyclic compound for prevention of PASK
Document Type and Number:
Japanese Patent JP6139415
Kind Code:
B2
Abstract:
Disclosed herein are substituted quinoxaline carboxylic acids of Formula (I): and compositions thereof, which may be useful as inhibitors of PAS Kinase (PASK) activity in a human or animal for the treatment of diseases such as diabetes mellitus.
Inventors:
John M McCall
Donna El Romero
Robert Sea Kelly
Donna El Romero
Robert Sea Kelly
Application Number:
JP2013556883A
Publication Date:
May 31, 2017
Filing Date:
March 02, 2012
Export Citation:
Assignee:
Bio energetics
International Classes:
C07D241/44; A61K31/498; A61K31/5377; A61K31/55; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P9/12; A61P43/00; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D403/14; C07D405/04; C07D405/12; C07D405/14; C07D409/04; C07D409/14; C07D413/04; C07D417/04
Domestic Patent References:
| JP2014505053A | ||||
| JP2014500323A | ||||
| JP2013503896A | ||||
| JP2002534512A |
Foreign References:
| WO2005007099A1 | ||||
| WO1999042463A1 | ||||
| US20090082356 | ||||
| WO2010101230A1 |
Other References:
Vitale, Gabriella et al.,Quinoxaline chemistry. Part 10. Quinoxaline 10-oxa-analogs of trimetrexate (TMQ) and of 5,8-dideazafolic acid. Synthesis and evaluation of in vitro anticancer activity,Il Farmaco,1998年,vol.53 no.2,pp.150-159
Loriga, Mario et al.,Quinoxaline chemistry. Part 7. Quinoxalines containing 2-(aminobenzoate) and 2-[(aminobenzoyl)glutamate] substituents as classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity,Il Farmaco,1997年,vol.52 no.3,pp.157-166
Loriga, Mario et al.,Quinoxaline chemistry. Part 5. 2-(Substituted benzylamino)quinoxalines as nonclassical antifolate agents. Synthesis and evaluation of in vitro anticancer activity,Il Farmaco,1996年,vol.51 no.8,9,pp.559-568
Loriga, Mario et al.,Quinoxaline chemistry. Part 4. 2-(R)-Anilinoquinoxalines as nonclassical antifolate agents. Synthesis, structure elucidation and evaluation of in vitro anticancer activity,Il Farmaco,1995年,vol.50 no.5,pp.289-301
Loriga, Mario et al.,Quinoxaline chemistry. Part 7. Quinoxalines containing 2-(aminobenzoate) and 2-[(aminobenzoyl)glutamate] substituents as classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity,Il Farmaco,1997年,vol.52 no.3,pp.157-166
Loriga, Mario et al.,Quinoxaline chemistry. Part 5. 2-(Substituted benzylamino)quinoxalines as nonclassical antifolate agents. Synthesis and evaluation of in vitro anticancer activity,Il Farmaco,1996年,vol.51 no.8,9,pp.559-568
Loriga, Mario et al.,Quinoxaline chemistry. Part 4. 2-(R)-Anilinoquinoxalines as nonclassical antifolate agents. Synthesis, structure elucidation and evaluation of in vitro anticancer activity,Il Farmaco,1995年,vol.50 no.5,pp.289-301
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Sakurai Yoko
Takuji Yamada
Michiko Matsutani
Sakurai Yoko