Title:
The human antibody to a glucagon receptor
Document Type and Number:
Japanese Patent JP6100697
Kind Code:
B2
Abstract:
The present invention provides antibodies that bind to the human glucagon receptor, designated GCGR and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human GCGR. The antibodies of the invention are useful for lowering blood glucose levels and blood ketone levels and are also useful for the treatment of diseases and disorders associated with one or more GCGR biological activities, including the treatment of diabetes, diabetic ketoacidosis and long-term complications associated with diabetes, or other metabolic disorders characterized in part by elevated blood glucose levels.
Inventors:
Haruka Okamoto
Mark Sleeman
Joyce Harp
Mark Sleeman
Joyce Harp
Application Number:
JP2013541008A
Publication Date:
March 22, 2017
Filing Date:
November 22, 2011
Export Citation:
Assignee:
REGENERON PHARMACEUTICALS, INC.
International Classes:
C12N15/09; A61K39/395; A61P3/04; A61P3/10; A61P9/00; A61P9/10; A61P13/12; A61P17/02; A61P25/00; A61P27/02; A61P27/12; C07K16/28; C07K16/46; C12P21/08
Domestic Patent References:
| JP8500737A |
Foreign References:
| US20020106629 |
Other References:
BUGGY J,HUMAN GLUCAGON RECEPTOR MONOCLONAL ANTIBODIES : ANTAGONISM OF GLUCAGON ACTION 以下備考,HORMONE AND METABOLIC RESEARCH,ドイツ,THIEME-STRATTON,1996年 1月 1日,V28 N5,P215-219,AND USE IN RECEPTOR CHARACTERIZATION
BRAND C L,IMMUNONEUTRALIZATION OF ENDOGENOUS GLUCAGON WITH MONOCLONAL GLUCAGON ANTIBODY 以下備考,DIABETOLOGIA,ドイツ,SPRINGER,1994年 1月 1日,V37 N10,P985-993,NORMALIZES HYPERGLYCAEMIA IN MODERATELY STREPTOZOTOCIN-DIABETIC RATS
BRAND C L,IMMUNONEUTRALIZATION OF ENDOGENOUS GLUCAGON WITH MONOCLONAL GLUCAGON ANTIBODY 以下備考,DIABETOLOGIA,ドイツ,SPRINGER,1994年 1月 1日,V37 N10,P985-993,NORMALIZES HYPERGLYCAEMIA IN MODERATELY STREPTOZOTOCIN-DIABETIC RATS
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
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