Title:
ヒストンデアセチラーゼ(HDAC)阻害剤としてのヒドロキサム酸誘導体
Document Type and Number:
Japanese Patent JP2006518341
Kind Code:
A
Abstract:
A compound having the following formula (I): wherein R1 is N-containing heterocyclic ring optionally substituted with one or more suitable substituent(s), R2 is hydroxyamino, R3 is hydrogen or a suitable substituent, L1 is -(CH2)n- (wherein n is an integer of 0 to 6) optionally substituted with one or more suitable substituent(s), wherein one or more methylene(s) may be replaced with suitable heteroatom(s), and L2 is lower alkenylene, or a salt thereof. The compound is useful as a histone deacetylase inhibitor.
Inventors:
Taiji Urano
Shigeki Sato
Naoki Ishibashi
Ikki Kamijo
Shigeki Sato
Naoki Ishibashi
Ikki Kamijo
Application Number:
JP2006500390A
Publication Date:
August 10, 2006
Filing Date:
January 13, 2004
Export Citation:
Assignee:
Astellas Pharma Inc.
International Classes:
C07D233/64; A61K31/36; A61K31/4164; A61K31/4178; A61K31/4188; A61K31/437; A61K31/44; A61K31/4406; A61K31/4439; A61K31/454; A61K31/496; A61K31/513; A61K31/522; A61K31/5377; A61P1/16; A61P3/10; A61P7/06; A61P11/00; A61P29/00; A61P33/02; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00; C07C57/58; C07C61/40; C07C211/50; C07C211/52; C07C233/22; C07C233/31; C07C233/43; C07C233/44; C07C233/51; C07C271/28; C07D213/40; C07D213/75; C07D233/54; C07D233/58; C07D233/68; C07D233/70; C07D233/90; C07D235/08; C07D235/10; C07D235/12; C07D235/16; C07D239/46; C07D317/66; C07D401/04; C07D403/04; C07D405/12; C07D405/14; C07D409/04; C07D471/04; C07D473/08; C07D491/04; C07D491/056
Attorney, Agent or Firm:
Takashima Ichi