Title:
O-デスメチルベンラファキシンの単離されたヒドロキシおよびN-オキシド代謝産物および誘導体および治療方法
Document Type and Number:
Japanese Patent JP2010507667
Kind Code:
A
Abstract:
The present invention provides novel isolated compounds characterized as metabolites or derivatives of desmethylvenlafaxine including hydroxy-DV metabolites, hydroxy-DV-glucuronide metabolites, N-oxide-DV metabolites, and benzyl-hydroxy-DV metabolites. The invention includes pharmaceutical compositions comprising any of the metabolites or derivatives of the invention in combination with a pharmaceutically acceptable carrier or excipient. The invention also includes a method of treating at least one central nervous system disorder in a mammal comprising providing to a mammal in need thereof an effective amount of the compounds of the invention.
Inventors:
Matthew John Hoffman
William Demio
Jim One
John William Ulrich
William Demio
Jim One
John William Ulrich
Application Number:
JP2009534631A
Publication Date:
March 11, 2010
Filing Date:
October 24, 2007
Export Citation:
Assignee:
Weiss LRC
International Classes:
C07C215/64; A61K31/137; A61K31/7034; A61P25/00; C07C233/18; C07C291/04; C07C305/20; C07C305/24; C07H7/033; A61P13/00; A61P25/04; A61P25/08; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P25/34
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita