Title:
An improved specific human double singularity EGFRvIII antibody joint molecule
Document Type and Number:
Japanese Patent JP6242484
Kind Code:
B2
Abstract:
We have constructed a polynucleotide encoding a bispecific antibody engaging molecule which has one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The polynucleotide is codon optimized for expression in CHO cells. The subunits of the engaging molecules are organized to achieve greater efficiency. These are promising therapeutic agents.
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Inventors:
Bigner Darrell Dee.
Sampson John
Kuan Cheng Tung
Kai Minkin
Choi Brian Dee.
Gedeon Patrick C.
Pastan Ira H.
Sampson John
Kuan Cheng Tung
Kai Minkin
Choi Brian Dee.
Gedeon Patrick C.
Pastan Ira H.
Application Number:
JP2016525458A
Publication Date:
December 06, 2017
Filing Date:
July 09, 2014
Export Citation:
Assignee:
DUKE UNIVERSITY
THE UNITED STATES OF AMERICA
THE UNITED STATES OF AMERICA
International Classes:
C12N15/09; A61K39/395; A61P35/00; C07K16/28; C07K16/30; C07K16/46; C12P21/08
Foreign References:
| US20120189630 | ||||
| WO2005010151A1 | ||||
| WO2005118635A1 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
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