Title:
アスパルチルプロテアーゼのインヒビター
Document Type and Number:
Japanese Patent JP4503896
Kind Code:
B2
Abstract:
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
Inventors:
Hale, Michael Robin
Chun, Roger
Price, Stephen
Wilkes, Robin David
Skyler, Wayne Curl
Jarvis, Ashley Nicholas
Spartenstein, Andrew
Far Fine, Eric Stephen
Samano, Vicente
Caldor, Istvan
Miller, John Franklin
Breger, Michael Stephen
Chun, Roger
Price, Stephen
Wilkes, Robin David
Skyler, Wayne Curl
Jarvis, Ashley Nicholas
Spartenstein, Andrew
Far Fine, Eric Stephen
Samano, Vicente
Caldor, Istvan
Miller, John Franklin
Breger, Michael Stephen
Application Number:
JP2001503821A
Publication Date:
July 14, 2010
Filing Date:
June 08, 2000
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
C07C311/18; C07D317/62; A61K31/34; A61K31/343; A61K31/352; A61K31/36; A61K31/5377; A61K45/06; A61P31/12; A61P31/18; A61P43/00; C07D317/46; C07D407/12; C07D493/04; A61K; A61P; C07C; C07D
Domestic Patent References:
| JP8501288A | ||||
| JP6502860A | ||||
| JP5345775A | ||||
| JP63112548A |
Foreign References:
| WO1995006030A1 | ||||
| WO1999010373A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto