Intramolecular cyclization-controlled release of HNO by elimination

Title:

Intramolecular cyclization-controlled release of HNO by elimination

Document Type and Number:

Japanese Patent JP6306602

Kind Code:

B2

Abstract:

Protected HNO donors designed to undergo non-enzymatic release at neutral pH via an intramolecular cyclization-elimination are disclosed. The rate of cyclization, and therefore HNO release, can be controlled by substituents and chain length. Thus, biologically useful HNO donors having tunable HNO release rates are provided.

Inventors:

Toscano, John Pea.
Sutton, Art Dee.

Application Number:

JP2015540750A

Publication Date:

April 04, 2018

Filing Date:

October 30, 2013

Export Citation:

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