Title:
The interferon yield inducer containing lactic acid bacteria
Document Type and Number:
Japanese Patent JP5950827
Kind Code:
B2
Abstract:
This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as Lactococcus garvieae NBRC100934, Lactococcus lactis subsp. cremoris JCM16167, Lactococcus lactis subsp. cremoris NBRC100676, Lactococcus lactis subsp. hordniae JCM1180, Lactococcus lactis subsp. hordniae JCM11040, Lactococcus lactis subsp. lactis NBRC12007, Lactococcus lactis subsp. lactis NRIC1150, Lactococcus lactis subsp. lactis JCM5805, Lactococcus lactis subsp. lactis JCM20101, Leuconostoc lactis NBRC12455, Leuconostoc lactis NRIC1540, Pediococcus damnosus JCM5886, or Streptococcus thermophilus TA-45.
Inventors:
Daisuke Fujiwara
Kenta Jouchi
Satoshi Sugimura
Kenta Jouchi
Satoshi Sugimura
Application Number:
JP2012551033A
Publication Date:
July 13, 2016
Filing Date:
December 28, 2011
Export Citation:
Assignee:
Kirin Holdings Company, Limited
Koiwai Dairy Co., Ltd.
Koiwai Dairy Co., Ltd.
International Classes:
A61K35/74; A61K35/744; A61K35/747; A61P31/12; A61P37/04; A61P43/00
Domestic Patent References:
| JP2009296972A | 2009-12-24 | |||
| JPWO2008099544A1 | 2010-05-27 |
Foreign References:
| WO2009007515A1 | 2009-01-15 |
Other References:
JPN6012009108; Ｌａｍｍｅｒｓ Ｋ， ｅｔ ａｌ．: 'ＤＮＡ ｄｅｒｉｖｅｄ ｆｒｏｍ ｐｒｏｂｉｏｔｉｃ ｂａｃｔｅｒｉａ ｍｏｄｕｌａｔｅｓ ｈｕｍａｎ ｄｅｎｄｒｉｔｉｃ ｃｅｌｌ ｐｈｅｎｏｔｙｐｅ ａｎｄ ｆｕｎｃｔｉｏｎ' Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ Ｖｏｌ． １２６， Ｎｏ． ４, 200404, ｐ． Ａ５１７ （＃Ｔ１８１５）
JPN6012009109; Ｔｏｋｉ Ｓ， ｅｔ ａｌ．: 'Ｇｅｎｅ ｅｘｐｒｅｓｓｉｏｎ ｐｒｏｆｉｌｅｓ ｉｎ ｔｈｅ ｐｌａｓｍａｃｙｔｏｉｄ ｄｅｎｄｒｉｔｉｃ ｃｅｌｌｓ ｓｔｉｍｕｌａｔｅｄ ｗｉｔｈ Ｌａｃｔｏｂａｃｉｌｌｕｓ ＧＧ ｏｒ Ｅ．ｃ' Ｊｏｕｒｎａｌ ｏｆ Ａｌｌｅｒｇｙ ａｎｄ Ｃｌｉｎｉｃａｌ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ． １１９， Ｎｏ． １, 200701, ｐ． Ｓ２５９ （＃１０１３）
JPN6012009110; Ｋｉｍｏｔｏ-Ｎｉｒａ Ｈ， ｅｔ ａｌ．: 'Ａｎｔｉ-ａｇｅｉｎｇ ｅｆｆｅｃｔ ｏｆ ａ ｌａｃｔｏｃｏｃｃａｌ ｓｔｒａｉｎ： ａｎａｌｙｓｉｓ ｕｓｉｎｇ ｓｅｎｅｓｃｅｎｃｅ-ａｃｃｅｌｅｒａｔｅｄ ｍｉｃｅ' Ｂｒｉｔｉｓｈ Ｊｏｕｒｎａｌ ｏｆ Ｎｕｔｒｉｔｉｏｎ Ｖｏｌ． ９８， Ｎｏ． ６, 200712, ｐ． １１７８-１１８６
JPN6012009111; Ｅｎｏｍｏｔｏ Ａ， ｅｔ ａｌ．: 'ＳＫＧマウスの脾臓細胞のサイトカイン産生応答に及ぼす乳酸菌の効果' 日本免疫学会総会・学術集会記録 Ｖｏｌ． ３８, 20081105, ｐ． １７４ （２Ｇ-Ｗ２９-１１-Ｐ）
JPN6012009112; 丸尾俊也， ｅｔ ａｌ．: 'Ｌａｃｔｏｃｏｃｃｕｓ ｌａｃｔｉｓ ｓｕｂｓｐ． ｃｒｅｍｏｒｉｓ ＦＣ 株牛乳発酵物の経口投与がインフルエンザウイルス感染モデルマウス' 日本食品科学工学会大会講演集 Ｖｏｌ． ５７ｔｈ, 20100901, ｐ． １０６ （２Ｅｐ８）
JPN6012009113; Ｌｅｉ Ｈ， ｅｔ ａｌ．: 'Ｉｍｍｕｎｏｐｒｏｔｅｃｔｉｏｎ ａｇａｉｎｓｔ ｉｎｆｌｕｅｎｚａ Ｈ５Ｎ１ ｖｉｒｕｓ ｂｙ ｏｒａｌ ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｏｆ ｅｎｔｅｒｉｃ-ｃｏａｔｅｄ ｒｅｃｏｍｂｉｎａｎｔ Ｌ' Ｖｉｒｏｌｏｇｙ Ｖｏｌ． ４０７， Ｎｏ． ２, 20101125, ｐ． ３１９-３２４
JPN6012009109; Ｔｏｋｉ Ｓ， ｅｔ ａｌ．: 'Ｇｅｎｅ ｅｘｐｒｅｓｓｉｏｎ ｐｒｏｆｉｌｅｓ ｉｎ ｔｈｅ ｐｌａｓｍａｃｙｔｏｉｄ ｄｅｎｄｒｉｔｉｃ ｃｅｌｌｓ ｓｔｉｍｕｌａｔｅｄ ｗｉｔｈ Ｌａｃｔｏｂａｃｉｌｌｕｓ ＧＧ ｏｒ Ｅ．ｃ' Ｊｏｕｒｎａｌ ｏｆ Ａｌｌｅｒｇｙ ａｎｄ Ｃｌｉｎｉｃａｌ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ． １１９， Ｎｏ． １, 200701, ｐ． Ｓ２５９ （＃１０１３）
JPN6012009110; Ｋｉｍｏｔｏ-Ｎｉｒａ Ｈ， ｅｔ ａｌ．: 'Ａｎｔｉ-ａｇｅｉｎｇ ｅｆｆｅｃｔ ｏｆ ａ ｌａｃｔｏｃｏｃｃａｌ ｓｔｒａｉｎ： ａｎａｌｙｓｉｓ ｕｓｉｎｇ ｓｅｎｅｓｃｅｎｃｅ-ａｃｃｅｌｅｒａｔｅｄ ｍｉｃｅ' Ｂｒｉｔｉｓｈ Ｊｏｕｒｎａｌ ｏｆ Ｎｕｔｒｉｔｉｏｎ Ｖｏｌ． ９８， Ｎｏ． ６, 200712, ｐ． １１７８-１１８６
JPN6012009111; Ｅｎｏｍｏｔｏ Ａ， ｅｔ ａｌ．: 'ＳＫＧマウスの脾臓細胞のサイトカイン産生応答に及ぼす乳酸菌の効果' 日本免疫学会総会・学術集会記録 Ｖｏｌ． ３８, 20081105, ｐ． １７４ （２Ｇ-Ｗ２９-１１-Ｐ）
JPN6012009112; 丸尾俊也， ｅｔ ａｌ．: 'Ｌａｃｔｏｃｏｃｃｕｓ ｌａｃｔｉｓ ｓｕｂｓｐ． ｃｒｅｍｏｒｉｓ ＦＣ 株牛乳発酵物の経口投与がインフルエンザウイルス感染モデルマウス' 日本食品科学工学会大会講演集 Ｖｏｌ． ５７ｔｈ, 20100901, ｐ． １０６ （２Ｅｐ８）
JPN6012009113; Ｌｅｉ Ｈ， ｅｔ ａｌ．: 'Ｉｍｍｕｎｏｐｒｏｔｅｃｔｉｏｎ ａｇａｉｎｓｔ ｉｎｆｌｕｅｎｚａ Ｈ５Ｎ１ ｖｉｒｕｓ ｂｙ ｏｒａｌ ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｏｆ ｅｎｔｅｒｉｃ-ｃｏａｔｅｄ ｒｅｃｏｍｂｉｎａｎｔ Ｌ' Ｖｉｒｏｌｏｇｙ Ｖｏｌ． ４０７， Ｎｏ． ２, 20101125, ｐ． ３１９-３２４
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Natsuo Tanaka
Satoshi Fujita
Natsuo Tanaka
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