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Patent Searching and Data


Title:
細胞内エレクトロマニピュレーション方法
Document Type and Number:
Japanese Patent JP5503575
Kind Code:
B2
Abstract:
A method for intracellular electro-manipulation is provided. The method includes applying at least one ultrashort electric field pulse to target cells. The ultrashort electric field pulse has sufficient amplitude and duration to modify subcellular structures in the target cells and does not exceed the breakdown field of the medium containing the target cells. The amplitude and duration of the ultrashort electric field pulse are typically insufficient to substantially alter permeability of the surface membranes of the target cells, e.g., by irreversibly disrupting the cell surface membranes. An apparatus for intracellular electro-manipulation is also provided. The apparatus includes a pulse generator capable of producing an ultrashort electric pulse output and a delivery system capable of directing the electric pulse output to target cells.

Inventors:
Bebe Stefan Jay.
Schoenbach Karl H.
View Shay. Stefan
Application Number:
JP2011036521A
Publication Date:
May 28, 2014
Filing Date:
February 23, 2011
Export Citation:
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Assignee:
Eastern Virginia Medical School of the Medical College of Hampton Rose
OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
International Classes:
A61N1/40; C12N13/00; A61B18/12; A61K41/00; A61P3/04; A61P35/00; C12N5/071; C12R1/91
Other References:
DANIEL PALANKER,ELECTRICAL ALTERNATIVE TO PULSED FIBER-DELIVERED LASERS IN MICROSURGERY,JOURNAL OF APPLIED PHYSICS,1997年 6月 1日,V81 N11,P7673-7680
Attorney, Agent or Firm:
Hatsushi Shimizu