Title:
粒子サイズ制御結晶化による鏡像異性体混合物からの鏡像異性体成分の単離方法
Document Type and Number:
Japanese Patent JP2011529469
Kind Code:
A
Abstract:
The present invention discloses a process for isolating enantiomer components from a mixture of enantiomers through particle-size-controlled crystallization, comprising the steps of: (a) forming a solution of a mixture of enantiomers (R) and (S) in a solvent in the absence of any further additives or agents; (b) seeding the solution of step (a) simultaneously or consecutively with seed crystals of enantiomer (R) and with seed crystals of enantiomer (S), wherein the seed crystals of enantiomer (R) differ in size and/or in quantity from the seed crystals of enantiomer (S) to allow separation of the crystals composed of a mixture enriched with enantiomer (R) from the crystals composed of a mixture enriched with enantiomer (S); (c) inducing simultaneous crystallization of enantiomer (R) and enantiomer (S); and (d) isolating crystals composed of a mixture enriched with enantiomer (R) from crystals composed of a mixture enriched with enantiomer (S) through size separation of the crystals, preferably through sieving, melting or sedimentation, in particular through sieving.
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Inventors:
Mayard, David
Koller, Guntram
Vacaresco, Yev Genie
Gottburg-Reininger, Sabine
Koller, Guntram
Vacaresco, Yev Genie
Gottburg-Reininger, Sabine
Application Number:
JP2011520493A
Publication Date:
December 08, 2011
Filing Date:
July 28, 2009
Export Citation:
Assignee:
POXEL SAS
International Classes:
C07C29/78; C07C33/26; C07D251/10; C07B57/00
Domestic Patent References:
| JP2005324082A | 2005-11-24 | |||
| JPS379069B1 | ||||
| JPH0219339A | 1990-01-23 | |||
| JP2006522753A | 2006-10-05 |
Other References:
JPN6013046151; Ｊｏｕｒｎａｌ ｏｆ Ｈｉｇｈ Ｒｅｓｏｌｕｔｉｏｎ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ ２１（７）, 1998, ４１４-４１６
JPN6013046153; 社団法人日本化学会: 標準化学用語辞典 , 1991, ６４９頁, 丸善株式会社
JPN6013046153; 社団法人日本化学会: 標準化学用語辞典 , 1991, ６４９頁, 丸善株式会社
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Fusayuki Saito