スフィンゴ脂質のポリアルキルアミン抱合体

Japanese Patent JP2006527763

A

The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for modulating the immune response of a subject. Other aspects of the invention concern methods for modulating the immune response of a subject by the use of the conjugate, complexes comprising, the sphingoid-polyalkylamine conjugate in combination with a biologically active molecule capable of modulating an immune response of a subject, compositions comprising the conjugate as well as kits making use of said conjugate. A preferred conjugate according to the invention is N palmitoyl D-erythro sphingosyl 1 carbamoyl spermine.

Barrenholtz, Yechezkel
Simberg, Dmitri
Roclin, Elimelek

JP2006516809A

December 07, 2006

June 17, 2004

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YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
Biolab Limited

C07C271/20; A61K9/127; A61K31/132; A61K38/47; A61K39/08; A61K39/145; A61K39/29; A61K39/39; A61K47/18; A61K48/00; A61P37/02; A61P43/00; C07C269/04; C07D273/00; C07B61/00

JP2001213858A	2001-08-07
JPH09508900A	1997-09-09
JPH02292246A	1990-12-03
JPH08509953A	1996-10-22
JPH10510813A	1998-10-20
JPH11507659A	1999-07-06
JP2001515060A	2001-09-18
JP2006527761A	2006-12-07
JP2006527762A	2006-12-07

WO2003066068A1	2003-08-14
US6075012A	2000-06-13
WO1999002190A1	1999-01-21
WO2000037046A1	2000-06-29

Takehiko Suzue
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Ryo Hashimoto
Tetsuya Kazama

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