Title:
IκBキナーゼ阻害剤
Document Type and Number:
Japanese Patent JP5140231
Kind Code:
B2
Abstract:
To provide an IκB kinase inhibitor inhibiting IκB kinase (a) causing NF-κB activation causing transcriptional enhancement of genes relating to immunity, inflammatory reaction, cell growth control and apoptosis, and (b) having inhibition of intracellular signaling of insulin and such properties as causing IRS-1 hypofunction (phosphorylation) causing inhibition of sugar intake into cells.
The IκB kinase inhibitor containing at least one selected from extracts, extracted from fruits or pericarps of a mangosteen (Garcinia mangostana L.), α-mangosteen and γ-mangosteen is provided, and a composition containing the inhibitor is provided.
COPYRIGHT: (C)2006,JPO&NCIPI
Inventors:
Oizumi Yasushi
Tohru Yamaguni
Tsutomu Arakawa
Kenji Osawa
Susumu Shimura
Tohru Yamaguni
Tsutomu Arakawa
Kenji Osawa
Susumu Shimura
Application Number:
JP2004114624A
Publication Date:
February 06, 2013
Filing Date:
April 08, 2004
Export Citation:
Assignee:
Lotte Co., Ltd.
International Classes:
A61K36/18; C12N9/99; A23L29/00; A61K31/352; A61K36/00; A61P1/04; A61P3/10; A61P5/14; A61P9/00; A61P9/10; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P21/00; A61P21/04; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P31/12; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P37/00; A61P37/02; A61P37/08; A61P43/00; C07D311/86
Domestic Patent References:
| JP200247180A | ||||
| JP2001247469A | ||||
| JP1072357A | ||||
| JP10120586A | ||||
| JP10203977A | ||||
| JP8208501A | ||||
| JP8231396A | ||||
| JP2005295991A |
Other References:
Nature、1998、Vol.396、p.77-80
J.Biol.Chem.、1999、Vol.274、No.38、p.27307-27314
J.Pharmacol.Sci.、2003、Vol.91、Supplement1、p.168P(1P336)
J.Biol.Chem.、1999、Vol.274、No.38、p.27307-27314
J.Pharmacol.Sci.、2003、Vol.91、Supplement1、p.168P(1P336)
Attorney, Agent or Firm:
Haruo Hamada