Title:
ＴＡＦＩａの阻害剤としての大環状尿素誘導体、それらの製造および医薬としての使用
Document Type and Number:
Japanese Patent JP6461113
Kind Code:
B2
Abstract:
The present invention relates to macrocydic urea derivatives of the formula I (I) in which R1, R2, R3, V and Y are as defined below. The compounds of the formula I are inhibitors of the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor). The invention further relates to the process for the preparation of the compounds of formula I and to the use thereof as medicaments.
Inventors:
Andreas Evers
Christopher Callus
Michael Wagner
Helmut Wilan
Christopher Callus
Michael Wagner
Helmut Wilan
Application Number:
JP2016517597A
Publication Date:
January 30, 2019
Filing Date:
June 05, 2014
Export Citation:
Assignee:
SANOFI
International Classes:
C07D273/01; A61K31/395; A61K31/4427; A61P3/00; A61P3/10; A61P7/00; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P17/02; A61P19/02; A61P29/00; A61P31/04; A61P35/00; A61P35/04; C07D413/12
Domestic Patent References:
| JP2011521981A | ||||
| JP2010511641A | ||||
| JP2011519818A | ||||
| JP2009528353A |
Other References:
Violeta, I. et al.,J. Org. Chem.,2010年,vol.75,p.1612-1619
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi