Title:
【発明の名称】RAGEのリガンド結合部位及びその使用
Document Type and Number:
Japanese Patent JP2001519401
Kind Code:
A
Abstract:
The present method provides for an isolated peptide having an amino acid sequence corresponding to the amino acid sequence of a V-domain of a receptor for advanced glycation end product (RAGE). The present invention also provides for an isolated peptide having an amino acid sequence A-Q-N-I-T-A-R-I-G-E-P-L-V-L-K-C-K-G-A-P-K-K-P-P-Q-R-L-E-W-K (Seq. ID No. 1). The present invention provides for a pharmaceutical composition comprising a therapeutically effect amount of an isolated peptide having an amino acid sequence corresponding to the amino acid sequence of a V-domain of RAGE. The present invention also provides for a method for inhibiting interaction of an amyloid-² peptide with a receptor for advanced glycation end product which is on the surface of a cell, which comprises contacting the cell with the peptide or a functionally equivalent agent, wherein the peptide or agent is capable of inhibiting interaction of the amyloid-² peptide with the receptor for advanced glycation end product, and the peptide or agent is present in an amount effective to inhibit interaction of the amyloid-² peptide with the receptor for advanced glycation end product.
Inventors:
Stern, david
Yang, Shi Do
Schmidt, Anne Marie
Ramster, Islay
Yang, Shi Do
Schmidt, Anne Marie
Ramster, Islay
Application Number:
JP2000515619A
Publication Date:
October 23, 2001
Filing Date:
October 09, 1998
Export Citation:
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
International Classes:
C12P21/08; A61K9/06; A61K9/08; A61K9/12; A61K9/14; A61K38/00; A61K39/395; A61K47/48; A61P1/02; A61P3/10; A61P9/10; A61P15/10; A61P17/02; A61P21/02; A61P25/28; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07K7/04; C07K14/705; C07K16/00; (IPC1-7): C07K7/04; A61K9/06; A61K9/08; A61K9/12; A61K9/14; A61K38/00; A61K39/395; A61K47/48; A61P1/02; A61P3/10; A61P9/10; A61P15/10; A61P17/02; A61P21/02; A61P25/28; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07K16/00; C12P21/08
Attorney, Agent or Firm:
Takehiko Suzue (4 outside)