Title:
1,2-ジアミノ-シクロヘキサン-白金(II)錯体の製造方法
Document Type and Number:
Japanese Patent JP2012530737
Kind Code:
A
Abstract:
The present invention is directed to a manufacturing process for 1,2-diamino-cyclohexane-platinum(II) complexes, specifically to a manufacturing process for oxaliplatin. The process is straightforward, economical and applicable to industrial production. It comprises the reaction of (DACH)PtCl 2 with silver sulfate (Ag 2 SO 4 ) and the subsequent reaction of the resulting Pt sulfate complex (DACH)Pt(aq) 2 SO 4 with barium oxalate (BaC 2 O 4 ) or an equimolar mixture of barium hydroxide and oxalic acid to yield oxaliplatin in high purity with a low silver and low nitrate content.
Inventors:
Nestor Pablo Sid
Miguel Julio Novas
Agustin Alfredo Tomei
Miguel Julio Novas
Agustin Alfredo Tomei
Application Number:
JP2012516565A
Publication Date:
December 06, 2012
Filing Date:
June 22, 2010
Export Citation:
Assignee:
Umicore AG & Co.KG
International Classes:
C07F15/00; C07C55/06; C07C211/36; A61K31/282; A61P35/04
Domestic Patent References:
| JP2005529958A | 2005-10-06 |
Foreign References:
| WO2007140804A1 | 2007-12-13 | |||
| EP0356332B1 | 1994-05-25 |
Attorney, Agent or Firm:
Takuya Kuno
Takahashi
Kiyoshi Kuruma
Kimihiro Hoshi
Hiroyasu Ninomiya
Ryoichi Shino
Ueshima
Einzel Felix-Reinhard
Takahashi
Kiyoshi Kuruma
Kimihiro Hoshi
Hiroyasu Ninomiya
Ryoichi Shino
Ueshima
Einzel Felix-Reinhard