Title:
1-(2-エチル-ブチル)-シクロヘキサンカルボン酸の製造方法
Document Type and Number:
Japanese Patent JP2010513371
Kind Code:
A
Abstract:
The present invention relates to a process for the preparation of 1-(2-ethyl-butyl)- cyclohexanecarboxylic acid which is useful as an intermediate in the preparation of pharmaceutical active compounds, wherein cyclohexanecarboxylic acid alkali metal salt reacts with an alkylating agent in the presence of a secondary amine and (C 1 -C 6 ) alkyllithium, (C 3 -C 6 ) cycloalkyllithium or phenyllithium.
Inventors:
Hoffman, Urzula
Lorry, bruno
Lorry, bruno
Application Number:
JP2009541970A
Publication Date:
April 30, 2010
Filing Date:
December 10, 2007
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07C51/353; B01J31/02; C07C51/41; C07C61/08; C07B61/00
Domestic Patent References:
| JPH1149743A | 1999-02-23 | |||
| JPS554365A | 1980-01-12 | |||
| JPH0269432A | 1990-03-08 |
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito
Koshiro Tsukuda
Fusayuki Saito