Title:
A manufacturing method of the 223Ra reagent of medicine allowable purity
Document Type and Number:
Japanese Patent JP5969462
Kind Code:
B2
Abstract:
The present invention relates to a method for the generation of 223 Ra of pharmaceutically tolerable purity comprising:
i) preparing a generator mixture comprising 227 Ac, 227 Th and 223 Ra in a first aqueous solution comprising a first mineral acid;
ii) loading said generator mixture onto a DGA separation medium (e.g. resin);
iii) eluting said 223 Ra from said DGA separation medium using a second mineral acid in a second aqueous solution to give an eluted 223 Ra solution; and
iv) stripping the DGA separation medium of said 227 Ac and 227 Th by flowing a third mineral acid in a third aqueous solution through the DGA separation medium in a reversed direction; The invention further relates to high purity radium-223 formed or formable by such a method as well as pharmaceutical compositions comprising such radium-223 of pharmaceutical purity.
Inventors:
Carlson, Jean, Roger
Borettzen, Pier
Borettzen, Pier
Application Number:
JP2013506544A
Publication Date:
August 17, 2016
Filing Date:
April 29, 2011
Export Citation:
Assignee:
Bayer Aes
International Classes:
G21G4/08; A61K51/00; A61N5/10; A61P35/00
Domestic Patent References:
| JP2002534399A | ||||
| JP2001318087A | ||||
| JP11253798A | ||||
| JP2006500553A | ||||
| JP2001239138A | ||||
| JP2005500518A |
Foreign References:
| US20070163957 | ||||
| US5809394 | ||||
| US20030194364 |
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe