Title:
エスシタロプラムの製造方法
Document Type and Number:
Japanese Patent JP4966933
Kind Code:
B2
Abstract:
This patent discloses a method for resolution of 4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a racemic or non-racemic enantiomer mixture into its isolated enantiomers, said method comprising the step of fractionally crystallising 4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a salt with the (+)-(S,S)-or (-)-(R,R)-enantiomer of O , O' -di- p -toluoyl-tartaric acid in a solvent system comprising 1-propanol, ethanol or acetonitrile.
Inventors:
Carla de Faveri
Florian Anton Martin Hoover
Robert james dancer
Florian Anton Martin Hoover
Robert james dancer
Application Number:
JP2008224435A
Publication Date:
July 04, 2012
Filing Date:
September 02, 2008
Export Citation:
Assignee:
Her Lundbeck Actiezer Scabet
International Classes:
C07C253/34; C07C255/59; C07D307/87; A61K31/343; C07B57/00
Foreign References:
| WO2006106531A1 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Taro Ushio
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Taro Ushio
Yasuhito Suzuki