Title:
Method for producing spirooxyindole derivative
Document Type and Number:
Japanese Patent JP6368311
Kind Code:
B2
Abstract:
The present invention is intended to provide a method for efficiently producing and providing a compound having a spirooxindole skeleton, for example, a compound having a spirooxindole skeleton and having antitumor activity that inhibits the interaction between Mdm2 protein and p53 protein, or an intermediate thereof, using an asymmetric catalyst. A compound having an optically active tricyclic dispiroindole skeleton is efficiently obtained through a catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.
Inventors:
Motoshi Yamauchi
Nakayama Keiji
Nakayama Keiji
Application Number:
JP2015535501A
Publication Date:
August 01, 2018
Filing Date:
September 03, 2014
Export Citation:
Assignee:
Daiichi Sankyo Co., Ltd.
International Classes:
C07D487/10; B01J31/24; C07B53/00; C07D491/20
Domestic Patent References:
| JP2013142071A |
Foreign References:
| WO2012121361A1 | ||||
| US20120071499 | ||||
| WO2012155066A1 |
Other References:
SHU,L. et al,Organic Process Research & Development,2013年 1月15日,Vol.17,pp.247-256
ANTONCHICK,A.P. et al.,Nature Chemistry,2010年 7月11日,Vol.2,pp.735-740
LIU,T-L. et al.,Organic & Biomolecular Chemistry,2011年,Vol.9,pp.1980-1986
LIU,J. et al.,Tetrahedron Letters,2012年,Vol.53,pp.2336-2340
Chemistry A European Journal,2012年,Vol.18,pp.8278-8282
ANTONCHICK,A.P. et al.,Nature Chemistry,2010年 7月11日,Vol.2,pp.735-740
LIU,T-L. et al.,Organic & Biomolecular Chemistry,2011年,Vol.9,pp.1980-1986
LIU,J. et al.,Tetrahedron Letters,2012年,Vol.53,pp.2336-2340
Chemistry A European Journal,2012年,Vol.18,pp.8278-8282
Attorney, Agent or Firm:
Kimiki Ishibashi
Noriko Kitano
Toshiyasu Takemoto
Hironobu Kodama
Reiko Kanehara
Noriko Kitano
Toshiyasu Takemoto
Hironobu Kodama
Reiko Kanehara
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