抗がん剤の製造方法

Japanese Patent JP5646606

B2

Disclosed is an antitumor agent which has higher antitumor activity than conventional antitumor agents, while having low toxicity. Specifically disclosed is an antitumor agent which is characterized by containing a phosphine transition metal complex that is represented by general formula (1). In general formula (1), it is preferable that the phosphine ligand is an (S,S)-2,3-bisphosphinoquinoxaline derivative. It is particularly preferable that the phosphine ligand is an (S,S)-2,3-bis(tert-butylmethylphosphino)quinoxaline. (In the formula, R1 and R2 each represents a linear or branched alkyl group, a cycloalkyl group, a cycloalkyl group having a substituent, an adamantyl group, a phenyl group or a phenyl group having a substituent and has 1-10 carbon atoms; R1 and R2 are different from each other, and R1 has a higher priority than R2 as ranked in accordance with the RS system; R3 and R4 each represents a hydrogen atom, or a linear or branched alkyl group and has 1-6 carbon atoms; R3 and R4 may be the same groups or different groups; R3 and R4 may combine together to form a saturated or unsaturated ring, and the saturated or unsaturated ring may have a substituent; M represents a transition metal atom that is selected from the group consisting of gold, copper and silver; and X- represents an anion.)

大原 宣彦
中對 一博
間山 大輔

JP2012510671A

December 24, 2014

April 13, 2011

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日本化学工業株式会社

A61K31/66; A61P35/00; C07B53/00; C07B57/00

JP2003300988A	2003-10-21
JP2010138136A	2010-06-24
JP2007056007A	2007-03-08
JP2007320909A	2007-12-13
JP2003300988A	2003-10-21
JP2010138136A	2010-06-24
JP2007056007A	2007-03-08

JPN6014030636; Ｔｅｔｒａｈｅｄｒｏｎ：　Ａｓｙｍｍｅｔｒｙ Ｖｏｌ．２１, 2010, １５２２-１５２８
JPN6014030636; Ｔｅｔｒａｈｅｄｒｏｎ：　Ａｓｙｍｍｅｔｒｙ Ｖｏｌ．２１, 2010, １５２２-１５２８

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