Title:
β-アミノ-α-ヒドロキシ-カルボン酸アミドの製造方法
Document Type and Number:
Japanese Patent JP4787795
Kind Code:
B2
Abstract:
Preparation of an amino-hydroxy-propionamide compound (I) comprises reacting an epoxy carboxylic acid amide compound (II) with an ammonia or an amine compound (III). JP2007332309AJP2007332309APreparation of an amino-hydroxy-propionamide compound of formula (I) comprises reacting an epoxy carboxylic acid amide compound of formula (II) with an ammonia or an amine compound (III) of formula (R 2>NH(R 3>)). Either R 1>-R 5>(1-8C)-alkyl, HO-(1-8C)-alkyl, (2-8C)-alkoxyalkyl, (6-18C)-aryl, (7-19C)-aralkyl, (3-18C)-heteroaryl, (4-19C)-heteroaralkyl, (1-8C)-alkyl-(6-18C)-aryl, (1-8C)-alkyl-(3-18C)-heteroaryl, (3-8C)-cycloalkyl, (1-8C)-alkyl-(3-8C)-cycloalkyl or (3-8C)-cycloalkyl-(1-8C)-alkyl; or R 4>R 5>, R 2>R 3>(2-8C)-alkylene bond. Provided that if R 4> and/or R 5> is H, then R 1>-R 4> is H and R 1> is not phenyl. Independent claims are included for: (1) an enantiomerically enriched 3-alkyl-oxirane carboxylic acid-N-cyclopropylamide compound of formula (IV) (where R is a linear (1-8C)-alkyl-residue); and (2) a salt of amino-hydroxy-cyclopropylamide compound of formula (V) with chiral acids. [Image] [Image].
Inventors:
Gunter Knaup
Application Number:
JP2007175902A
Publication Date:
October 05, 2011
Filing Date:
July 04, 2007
Export Citation:
Assignee:
Evonik Degussa GmbH
International Classes:
C07C231/12; C07B57/00; C07C237/04; C07C269/08; C07C271/22
Domestic Patent References:
| JP63267750A | ||||
| JP2000516575A | ||||
| JP2009132621A | ||||
| JP2009530282A |
Foreign References:
| US6025516 | ||||
| WO2006008170A1 | ||||
| WO2007138928A1 |
Other References:
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Bulletin of the Chemical Society of Japan,1981年,54(7),p.2136-2141
Archiv der Pharmazie,1979年,312(2),p.138-147
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Tetrahedron Letters,1996年,37(40),p.7311-7314
Bulletin of the Chemical Society of Japan,1981年,54(7),p.2136-2141
Archiv der Pharmazie,1979年,312(2),p.138-147
Archiv der Pharmazie,1979年,312(1),p.26-34
Bulletin de la Societe Chimique de France,1940年,7,p.593-603
Collection of Czechoslovak Chemical Communications,1972年,37(3),p.1035-1043
Nippon Kagaku Zasshi,1966年,87(7),p.767-768
Tetrahedron Letters,1996年,37(40),p.7311-7314
Attorney, Agent or Firm:
Takuya Kuno
Toshio Yano
Takahashi
Kimihiro Hoshi
Hiroyasu Ninomiya
Ryoichi Shino
Einzel Felix-Reinhard
Toshio Yano
Takahashi
Kimihiro Hoshi
Hiroyasu Ninomiya
Ryoichi Shino
Einzel Felix-Reinhard