Title:
CF2Oブリッジを有する化合物の製造方法
Document Type and Number:
Japanese Patent JP4970340
Kind Code:
B2
Abstract:
The invention relates to a process for the preparation of compounds containing at least one -CF2-O- bridge in the molecule, in which a) an acid is added onto at least one ketene dithioketal, b) the resultant bis(alkylthio)carbenium salt is reacted with at least one compound having at least one hydroxyl group in the presence of a base, c) and subsequently, preferably in situ, the resultant dithioorthoester is subjected to oxidative fluorodesulfurisation using a fluorinating agent and an oxidant to give the compound containing at least one -CF2-O- bridge in the molecule.
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Inventors:
Kirsch, Peel
Andreas, Taugerbeck
Hahn, alexander
Andreas, Taugerbeck
Hahn, alexander
Application Number:
JP2008124884A
Publication Date:
July 04, 2012
Filing Date:
May 12, 2008
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C07D339/08; C07B41/04; C07C41/16; C07C43/225; C07C45/59; C07C45/60; C07C49/467; C07C49/517; C07C49/753; C07C205/37; C07C253/30; C07C255/54; C07C323/15; C07C327/36; C07D317/72; C07D319/08; C07D319/14; C07D321/10; C07D409/06; C07D409/08; C09K19/30; C09K19/34; C09K19/42; C09K19/58
Domestic Patent References:
| JP2004515535A | ||||
| JP2003525286A |
Other References:
Journal of Medicinal Chemistry,1998年,41(6),p.821-835
Tetrahedron Letters,1974年,(36),p.3171-3174
Journal of Organic Chemistry,1978年,43(15),p.3065-3066
Tetrahedron,1978年,34(20),p.3081-3088
Tetrahedron Letters,1974年,(36),p.3171-3174
Journal of Organic Chemistry,1978年,43(15),p.3065-3066
Tetrahedron,1978年,34(20),p.3081-3088
Attorney, Agent or Firm:
Kiyoji Kuzuwa