Title:
ヒアルロン酸官能基化誘導体の製造方法及びそのヒドロゲル形成
Document Type and Number:
Japanese Patent JP5607061
Kind Code:
B2
Abstract:
In this invention a two steps procedure is described useful to insert functional groups to the hyaluronic acid (HA), through the formation, in organic solvent, of a particular active group on hydroxyl groups of HA and subsequent substitution, on the inserted active group, with a pendant portion containing at least in its terminal portion a nucleophilic functional group, NH2—R. The group inserted by nucleophilic substitution can contain in another its terminal portion a further nucleophilic functional group, in a way to be easily exploitable to further chemical functionalizations, such as an example to obtain the methacrylation of HA functional groups, to obtain photocrosslinkable derivatives. Both direct derivatives of the proposed process and those obtained by the further functionalization can be employed to produce hydrogels.
Inventors:
Jammu Mona Gaetano
パルムボ Fabio
ピタッレシ Giovanna
パルムボ Fabio
ピタッレシ Giovanna
Application Number:
JP2011537999A
Publication Date:
October 15, 2014
Filing Date:
November 30, 2009
Export Citation:
Assignee:
Uni-ヴァーシタ' デグリ Studi Di Palermo
International Classes:
A61K9/06; C08B37/08; A61K9/70; A61K47/36; A61K48/00; A61L15/00; A61L15/16; A61L27/00
Attorney, Agent or Firm:
Michio Nagai