Title:
光学活性2-アルキルシステインの製造方法、並びにその誘導体及び製造方法
Document Type and Number:
Japanese Patent JP4735263
Kind Code:
B2
Abstract:
There is provided a process for producing an optically active 2-alkylcysteine or a salt thereof, characterized by allowing cells of microorganism or treated products thereof having an activity of stereoselective hydrolysis of the amide bond of a 2-alkyl-L-cysteinamide or a salt thereof to act on a 2-alkylcysteinamide consisting of a mixture of D- and L-isomers or a salt thereof; and allowing the obtained 2-alkyl-L-cysteine and 2-alkyl-D-cysteinamide to react with an aldehyde or a ketone, or an acetal or ketal thereof, so as to derive therefrom a 4-alkylthiazolidine-4-carboxylic acid or a salt thereof and a 4-alkylthiazolidine-4-carboxamide or a salt thereof, thereby efficiently separating and obtaining a 2-alkyl-L-cysteine or a salt thereof, or a 2-alkyl-D-cysteine or a salt thereof. There is also provided a process for producing a 4-alkylthiazolidine-4-carboxylic acid or a salt thereof from the 2-alkylcysteine or a salt thereof.
Inventors:
Yasushi Higuchi
Akinori Tanaka
Takashi Hasemi
Masaki Sugita
Akinori Tanaka
Takashi Hasemi
Masaki Sugita
Application Number:
JP2005515637A
Publication Date:
July 27, 2011
Filing Date:
November 18, 2004
Export Citation:
Assignee:
Mitsubishi Gas Chemical Co., Ltd.
International Classes:
C12P41/00; C07B53/00; C07B57/00; C07C319/02; C07D277/06; C07D277/60; C12P13/12; C07C323/58
Domestic Patent References:
| JP2002348282A | 2002-12-04 |