Title:
METHOD OF MAKING NON-HUMAN ANIMAL WITH ABNORMALITY IN BRAIN TISSUE, AND USE THEREOF
Document Type and Number:
Japanese Patent JP2018093753
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method of making a non-human animal with abnormality in brain tissue, and use thereof.SOLUTION: The present invention provides a method of making a non-human animal with abnormality in brain tissue, the method including the step of administering, to a non-human animal, at least one material of saccharides selected from monosaccharides, disaccharides and oligosaccharides, and artificial sweeteners.SELECTED DRAWING: Figure 1
Inventors:
HIRAI SHINOBU
OKADO HARUO
MATSUMOTO YOSHIE
OKADO HARUO
MATSUMOTO YOSHIE
Application Number:
JP2016238899A
Publication Date:
June 21, 2018
Filing Date:
December 08, 2016
Export Citation:
Assignee:
TOKYO METROPOLITAN INST MEDICAL SCIENCE
International Classes:
A01K67/027; G01N33/15
Domestic Patent References:
| JP2012525385A | 2012-10-22 |
Foreign References:
| WO2015089443A2 | 2015-06-18 | |||
| WO2015061330A1 | 2015-04-30 |
Other References:
"Early and sustained exposure to high-sucrose diet triggers hippocampal ER stress in young rats", METABOLIC BRAIN DISEASE, vol. Vol.31, p.917-927, JPN6020032525, 7 May 2016 (2016-05-07), ISSN: 0004700424
"Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amy", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. Vol.282, No.50, p.36275-36282, JPN6020032526, 2007, ISSN: 0004700425
"High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumul", NEUROBIOLGY OF DISEASE, vol. Vol.89, p.65-75, JPN6020032527, 3 February 2016 (2016-02-03), ISSN: 0004700426
"Involvement of the Receptor for Advanced Glycation End-product (RAGE) in the Interaction Between Red", EARLY INTERVENTION IN PSYCHIATRY, vol. Vol.10, Supplement1, p.59, JPN6021020009, October 2016 (2016-10-01), ISSN: 0004700427
日薬理誌, vol. Vol.142, p.276-279, JPN7021001896, 2013, ISSN: 0004700428
CELL, vol. Vol.149, p.708-721, JPN6021020013, 2012, ISSN: 0004700429
"Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amy", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. Vol.282, No.50, p.36275-36282, JPN6020032526, 2007, ISSN: 0004700425
"High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumul", NEUROBIOLGY OF DISEASE, vol. Vol.89, p.65-75, JPN6020032527, 3 February 2016 (2016-02-03), ISSN: 0004700426
"Involvement of the Receptor for Advanced Glycation End-product (RAGE) in the Interaction Between Red", EARLY INTERVENTION IN PSYCHIATRY, vol. Vol.10, Supplement1, p.59, JPN6021020009, October 2016 (2016-10-01), ISSN: 0004700427
日薬理誌, vol. Vol.142, p.276-279, JPN7021001896, 2013, ISSN: 0004700428
CELL, vol. Vol.149, p.708-721, JPN6021020013, 2012, ISSN: 0004700429
Attorney, Agent or Firm:
Harakenzo world patent & trademark
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