Title:
A manufacturing method of optical activity alcohol
Document Type and Number:
Japanese Patent JP6038800
Kind Code:
B2
Abstract:
Provided is an industrially advantageous method for producing optically active alcohols in high yields from ketones of various structures by using an inexpensive chiral catalyst. The method of the present invention for producing optically active alcohols comprises reducing a ketone in the presence of an iridium(III) complex having a chiral prolinamide compound as a ligand. The ketone is preferably a compound represented by formula [I]:
(wherein R 1 and R 2 are different from each other, and each represent an optionally substituted straight or branched alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted aralkyl group, an optionally substituted heteroarylalkyl group, an optionally substituted alkenyl group or an optionally substituted alkynyl group, and
R 1 and R 2 may be bound to each other at any appropriate position to form a ring, the ring optionally containing one or more atoms which may be the same or different and are selected from an oxygen atom, an optionally substituted nitrogen atom and a sulfur atom, and optionally being condensed with an aromatic or hetero-aromatic ring).
More Like This:
Inventors:
Maeda Sadayuki
Tatsunori Sato
Tatsunori Sato
Application Number:
JP2013540803A
Publication Date:
December 07, 2016
Filing Date:
October 24, 2012
Export Citation:
Assignee:
Hamari Pharmaceutical Co., Ltd.
International Classes:
C07C29/143; C07C35/27; C07C41/26; C07C43/23
Foreign References:
| WO2002010101A1 |
Other References:
Katrin AHLFORD, Hans ADOLFSSON,Amino acid derived amides and hydroxamic acids as ligands for asymmetric transfer hydrogenation in a,Catalysis Communications,2011年 3月30日,Vol. 12,1118-1121
Charles V. MANVILLE, Gordon DOCHERTY, Ranbir PADDA, Martin WILLS,Application of Proline-Functionalised 1,2-Diphenylethane-1,2-diamine (DPEN) in Asymmetric Transfer H,European Journal of Organic Chemistry,2011年 8月10日,6893-6901
J. W. FALLER, Adrien R. LAVOIE,Catalysts for the Asymmetric Transfer Hydrogenation of Ketones Derived from L-Prolinamide and (p-Cym,Organometallics,2001年,Vol. 20,5245-5247
Charles V. MANVILLE, Gordon DOCHERTY, Ranbir PADDA, Martin WILLS,Application of Proline-Functionalised 1,2-Diphenylethane-1,2-diamine (DPEN) in Asymmetric Transfer H,European Journal of Organic Chemistry,2011年 8月10日,6893-6901
J. W. FALLER, Adrien R. LAVOIE,Catalysts for the Asymmetric Transfer Hydrogenation of Ketones Derived from L-Prolinamide and (p-Cym,Organometallics,2001年,Vol. 20,5245-5247
Attorney, Agent or Firm:
Ryu Iwatani
Previous Patent: 3D retina separation detection using an optical interference fault method
Next Patent: JPS6038801
Next Patent: JPS6038801