Title:
光学活性アミノアルコールの製造方法
Document Type and Number:
Japanese Patent JP4728548
Kind Code:
B2
Abstract:
An industrially advantageous process for producing optically active 4-amino-2-methylbutane-1-ol which is useful as an intermediate in synthesizing optically active medicines and pesticides. Racemic 4-amino-2-methylbutane-1-ol is treated with an optically active organic acid. The diastereomeric salt thus obtained is crystallized out and subjected to solid-liquid separation to give optically active 4-amino-2-methylbutane-1-ol. The diastereomeric salt of optically active 4-amino-2-methylbutane-1-ol with an optically active reagent for optical resolution is decomposed by bringing into contact with a solvent and an alkali and subjected to solid-liquid separation, thereby recovering the optically active 4-amino-2-methylbutane-1-ol from the filtrate. Further, the filtration residue containing the alkali salt of the reagent for optical resolution obtained by the solid-liquid separation is brought into contact with a solvent and an acid. Then the reagent for optical resolution thus crystallized out is subjected to solid-liquid separation and recovered.
Inventors:
Eiji Ozaki
Ryuichi Endo
Yamaguchi Yasumasa
Hamanaka Koji
Ryuichi Endo
Yamaguchi Yasumasa
Hamanaka Koji
Application Number:
JP2001521691A
Publication Date:
July 20, 2011
Filing Date:
September 07, 2000
Export Citation:
Assignee:
Mitsubishi Rayon Co., Ltd.
International Classes:
C07C213/10; C07C51/41; C07C215/08; C07B57/00
Domestic Patent References:
| JPH0859576A | 1996-03-05 | |||
| JPS56123936A | 1981-09-29 | |||
| JPS50111004A | 1975-09-01 | |||
| JPH09263585A | 1997-10-07 | |||
| JPS58174383A | 1983-10-13 | |||
| JPS5630952A | 1981-03-28 | |||
| JPS4522524B1 |
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Katsunori Ando
Yukihiro Ikeda
Hajime Asamura
Katsunori Ando
Yukihiro Ikeda